Document Detail

Sodium 5, 6-benzylidene-L-ascorbate induces in vitro neuronal cell differentiation accompanying apoptosis and necrosis.
MedLine Citation:
PMID:  12168819     Owner:  NLM     Status:  MEDLINE    
Antiproliferative activity through induction of differentiation by chemotherapeutic agents is required for certain types of cancers. Here, we report that a potent antitumor agent, sodium 5, 6-benzylidene-L-ascorbate (SBA), could induce morphological change of human neuroblastoma IMR-32 cells into a ganglion-like cell aggregate (pseudoganglion) having many neurites and the property of cholinergic neurons. Simultaneously with neuronal differentiation, substantial apoptosis and necrosis/type 2 physiological cell death, which is independent of apoptosis and resistant to a broad-spectrum caspase inhibitor, Z-Asp-CH2-DCB, were also observed. These data indicated that SBA could suppress tumor cell growth through the induction of three different physiological pathways such as differentiation, apoptosis and necrosis by which tissues and organs regulate their own development and maintenance.
Fumio Tashiro; Akinori Sugiyama; Yumiko Urano; Mutsuyuki Kochi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Anticancer research     Volume:  22     ISSN:  0250-7005     ISO Abbreviation:  Anticancer Res.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-08-09     Completed Date:  2002-09-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8102988     Medline TA:  Anticancer Res     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1423-31     Citation Subset:  IM    
Department of Biological Science and Technology, Science University of Tokyo, Noda, Chiba, Japan.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Apoptosis / drug effects*
Ascorbic Acid / analogs & derivatives*,  pharmacology*
Benzylidene Compounds / pharmacology*
Cell Differentiation / drug effects*
Cell Survival / drug effects
Neuroblastoma / drug therapy*,  pathology
Neurons / drug effects*,  pathology
Tumor Cells, Cultured
Reg. No./Substance:
0/Antineoplastic Agents; 0/Benzylidene Compounds; 20664-60-2/zilascorb; 50-81-7/Ascorbic Acid

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