Document Detail

Sodium-23 magnetic resonance imaging during and after transient cerebral ischemia: multinuclear stroke protocols for double-tuned (23)Na/(1)H resonator systems.
MedLine Citation:
PMID:  23044614     Owner:  NLM     Status:  Publisher    
A double-tuned (23)Na/(1)H resonator system was developed to record multinuclear MR image data during and after transient cerebral ischemia. (1)H-diffusion-, (1)H perfusion, (1)H T(2)-, (1)H arterial blood flow- and (23)Na spin density-weighted images were then acquired at three time points in a rodent stroke model: (I) during 90 min artery occlusion, (II) directly after arterial reperfusion and (III) one day after arterial reperfusion. Normal (23)Na was detected in hypoperfused stroke tissue which exhibited a low (1)H apparent diffusion coefficient (ADC) and no changes in (1)H T(2) relaxation time during transient ischemia, while (23)Na increased and ADC values recovered to normal values directly after arterial reperfusion. For the first time, a similar imaging protocol was set-up on a clinical 3T MRI site in conjunction with a commercial double-tuned (1)H/(23)Na birdcage resonator avoiding a time-consuming exchange of resonators or MRI systems. Multinuclear (23)Na/(1)H MRI data sets were obtained from one stroke patient during both the acute and non-acute stroke phases with an aquisition time of 22 min. The lesion exhibiting low ADC was found to be larger compared to the lesion with high (23)Na at 9 h after symptom onset. It is hoped that the presented pilot data demonstrate that fast multinuclear (23)Na/(1)H MRI preclinical and clinical protocols can enable a better understanding of how temporal and regional MRI parameter changes link to pathophysiological variations in ischemic stroke tissue.
Friedrich Wetterling; Saema Ansar; Eva Handwerker
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-09
Journal Detail:
Title:  Physics in medicine and biology     Volume:  57     ISSN:  1361-6560     ISO Abbreviation:  Phys Med Biol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0401220     Medline TA:  Phys Med Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  6929-6946     Citation Subset:  -    
RF Methods and Imaging Group, Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Faculty of Engineering, Trinity College, Dublin University, Dublin, Ireland.
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