Document Detail

Sodium-23 magnetic resonance brain imaging.
MedLine Citation:
PMID:  2259436     Owner:  NLM     Status:  MEDLINE    
This is a review of recent work in 23Na MR imaging. The main emphasis of recent papers has been pulse sequences that, with appropriate postprocessing, give images of the fast, slow, and intermediate components of T2 decay. The assignment of compartmental designation to the T2 component remains a problem except for homogeneous structures easily identifiable anatomically (ventricles, superior sagittal sinus, globe of the eye). Compartmental distribution of sodium is described. The predominance of the interstitial and plasma compartment, the invisibility of part of the intracellular sodium, and the difficulty in imaging the very fast T2 component of visible intracellular sodium make the usual Na spin-echo image essentially an image of the interstitial and plasma space. Use of super paramagnetic iron oxide coupled to dextran as a contrast medium may help to identify the plasma compartment. Because the usual Na MR images are essentially interstitial and plasma images, our own interest is in observing functional changes in these compartments. Another proposed application is the detection of the very fast T2 component in brain tumors to aid in defining tumor grade and extent.
S S Winkler
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuroradiology     Volume:  32     ISSN:  0028-3940     ISO Abbreviation:  Neuroradiology     Publication Date:  1990  
Date Detail:
Created Date:  1991-01-31     Completed Date:  1991-01-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1302751     Medline TA:  Neuroradiology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  416-20     Citation Subset:  IM    
Radiology Service, William S. Middleton Memorial Veterans Hospital, Madison, Wisconsin.
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MeSH Terms
Brain / metabolism*
Magnetic Resonance Spectroscopy* / methods
Sodium / metabolism*
Reg. No./Substance:

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