Document Detail

Socs36E attenuates STAT signaling to optimize motile cell specification in the Drosophila ovary.
MedLine Citation:
PMID:  23583584     Owner:  NLM     Status:  MEDLINE    
The Janus kinase/Signal transducers and activators of transcription (JAK/STAT) pathway determines cell fates by regulating gene expression. One example is the specification of the motile cells called border cells during Drosophila oogenesis. It has been established that too much or too little STAT activity disrupts follicle cell identity and cell motility, which suggests the signaling must be precisely regulated. Here, we find that Suppressor of cytokine signaling at 36E (Socs36E) is a necessary negative regulator of JAK/STAT signaling during border cell specification. We find when STAT signaling is too low to induce migration in the presumptive border cell population, nearby follicle cells uncharacteristically become invasive to enable efficient migration of the cluster. We generated a genetic null allele that reveals Socs36E is required in the anterior follicle cells to limit invasive behavior to an optimal number of cells. We further show Socs36E genetically interacts with the required STAT feedback inhibitor apontic (apt) and APT's downstream target, mir-279, and provide evidence that suggests APT directly regulates Socs36E transcriptionally. Our work shows Socs36E plays a critical role in a genetic circuit that establishes a boundary between the motile border cell cluster and its non-invasive epithelial neighbors through STAT attenuation.
Amanda J Monahan; Michelle Starz-Gaiano
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2013-04-10
Journal Detail:
Title:  Developmental biology     Volume:  379     ISSN:  1095-564X     ISO Abbreviation:  Dev. Biol.     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-10     Completed Date:  2013-08-13     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  0372762     Medline TA:  Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 Elsevier Inc. All rights reserved.
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MeSH Terms
Cell Differentiation / physiology*
Cell Movement / physiology
DNA Primers / genetics
DNA-Binding Proteins / metabolism
Drosophila Proteins / metabolism*
Drosophila melanogaster / embryology*
Electrophoretic Mobility Shift Assay
Fluorescent Antibody Technique
Gene Expression Regulation, Developmental / genetics,  physiology*
Ovarian Follicle / cytology,  physiology
Ovary / cytology,  embryology*
STAT Transcription Factors / metabolism*
Signal Transduction / genetics,  physiology*
Suppressor of Cytokine Signaling Proteins / metabolism*
Transcription Factors / metabolism
Grant Support
Reg. No./Substance:
0/DNA Primers; 0/DNA-Binding Proteins; 0/Drosophila Proteins; 0/STAT Transcription Factors; 0/Socs36E protein, Drosophila; 0/Suppressor of Cytokine Signaling Proteins; 0/Transcription Factors; 0/apontic protein, Drosophila

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