Document Detail

Sociodemographic and clinical factors associated with depression in epilepsy.
MedLine Citation:
PMID:  19233316     Owner:  NLM     Status:  MEDLINE    
The impact of mood disorders on patients with epilepsy is an important and growing area of research. If clinicians are adept at recognizing which patients with epilepsy are at risk for mood disorders, treatment can be facilitated and morbidity avoided. We completed a case-control study (80 depressed subjects, 141 nondepressed subjects) to determine the sociodemographic and clinical factors associated with self-reported depression in people with epilepsy. The Patient Health Questionnaire-9 was used to determine clinically significant depression. In multivariate analyses, depressed subjects with epilepsy were significantly less likely than nondepressed subjects to be married or employed and more likely to report comorbid medical problems and active seizures in the past 6 months. Adjusted for all other variables, subjects with epilepsy reporting lamotrigine use were significantly less likely to be depressed (OR=0.4, 95% CI: 0.2-0.8) compared with those not reporting lamotrigine use.
Alexander W Thompson; John W Miller; Wayne Katon; Naomi Chaytor; Paul Ciechanowski
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2009-02-20
Journal Detail:
Title:  Epilepsy & behavior : E&B     Volume:  14     ISSN:  1525-5069     ISO Abbreviation:  Epilepsy Behav     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-13     Completed Date:  2009-08-07     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  100892858     Medline TA:  Epilepsy Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
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MeSH Terms
Anticonvulsants / therapeutic use
Antidepressive Agents / therapeutic use
Case-Control Studies
Depression / epidemiology*,  therapy*
Epilepsy / epidemiology*,  therapy*
Logistic Models
Middle Aged
Psychiatric Status Rating Scales
Self Concept
Grant Support
T32 MH020021/MH/NIMH NIH HHS; T32 MH020021-10/MH/NIMH NIH HHS
Reg. No./Substance:
0/Anticonvulsants; 0/Antidepressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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