Document Detail

Sociodemographic and dietary risk factors for natural infant intussusception in the United States.
MedLine Citation:
PMID:  20562726     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In 1999, a US case-control study demonstrated a strong association between intussusception and a rotavirus vaccine (Rotashield). However, because most (87%) cases were not temporally associated with vaccination, we reanalyzed these data to assess risk factors for intussusception cases unrelated to Rotashield.
PATIENTS AND METHODS: Case-patients were infants with intussusception between November 1998 and June 1999. Controls were matched by age and hospital of birth. Sociodemographic and feeding practice data were collected through parent and provider interviews. Conditional logistic regression was used to identify risk factors for intussusception, controlling for exposure to Rotashield <21 days before intussusception.
RESULTS: Four hundred twenty-nine cases and 1763 controls were enrolled. Among case-patients, 372 (87%) had not received Rotashield within 21 days before intussusception. After adjusting for recent Rotashield administration, factors associated with intussusception included male sex (odds ratio [OR] 1.7; 95% confidence interval [CI] 1.3-2.2), Hispanic (OR 2.1; 95% CI 1.4-3.2) or black (OR 1.8; 95% CI 1.2-2.7) race/ethnicity, and Medicaid enrollment (OR 1.5; 95% CI 1.1-2.0). Feeding practices modified the risk of intussusception. Interaction was found between introduction of solid food (ISF) and type of formula consumption. Using breast milk as the referent group, infants with ISF for at least 5 weeks who consumed soy milk-based formula had a lower risk (OR 0.26; 95% CI 0.1-0.7) and infants without ISF who consumed cow's-milk formula had an increased risk (OR 2.33; 95% CI 1.4-3.9).
CONCLUSIONS: Risk of intussusception among US infants varies based on sociodemographic characteristics and feeding patterns.
Brian Johnson; Paul Gargiullo; Trudy V Murphy; Umesh D Parashar; Manish M Patel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric gastroenterology and nutrition     Volume:  51     ISSN:  1536-4801     ISO Abbreviation:  J. Pediatr. Gastroenterol. Nutr.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8211545     Medline TA:  J Pediatr Gastroenterol Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-63     Citation Subset:  IM    
National Center for Immunizations and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
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MeSH Terms
African Continental Ancestry Group / statistics & numerical data
Case-Control Studies
Diet / adverse effects*,  methods
Hispanic Americans / statistics & numerical data
Infant Food / adverse effects,  statistics & numerical data
Infant Formula / statistics & numerical data
Intussusception / epidemiology*
Medicaid / statistics & numerical data
Odds Ratio
Risk Factors
Sex Distribution
Socioeconomic Factors
Soy Milk / statistics & numerical data
United States / epidemiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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