Document Detail

Socio-economic versus obstetric risk factors for drug addiction in offspring.
MedLine Citation:
PMID:  1490081     Owner:  NLM     Status:  MEDLINE    
Two possible risk factors for drug addiction were weighed against each other: (1) perinatal factors associated with obstetric medication at time of birth; and (2) factors associated with familial socio-economic conditions at time of birth. The subjects comprised 200 amphetamine addicts and 200 opiate addicts born in Stockholm 1945-1966. In a matched case control study, addicts were compared to their siblings with regard to possible obstetric risk factors by means of conditional logistic regression controlling for socio-economic level and civil status. Administration of opiates, barbiturates and nitrous oxide to mothers during labour was associated with drug addiction in offspring, hence confirming results from earlier studies. In a cohort study the risk associated with birth at a given hospital and familial socio-economic level was analysed by means of log-linear analysis using 7100 controls from the general population. For amphetamine addicts, a low socio-economic level at time of birth might be of importance for the infant subsequently becoming an addict. This could not be demonstrated for the opiate addicts. An uneven distribution of births among the hospitals, most pronounced for the amphetamine addicts, is in agreement with the hypothesis that obstetric practices may be risk factors for adult drug addiction.
K Nyberg; P Allebeck; G Eklund; B Jacobson
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  British journal of addiction     Volume:  87     ISSN:  0952-0481     ISO Abbreviation:  Br J Addict     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-02     Completed Date:  1993-03-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8804404     Medline TA:  Br J Addict     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1669-76     Citation Subset:  IM    
Department of Clinical Alcohol and Drug Research, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Birth Weight
Child, Preschool
Hospital Records
Infant, Newborn
Middle Aged
Mother-Child Relations
Risk Factors
Socioeconomic Factors
Substance-Related Disorders / epidemiology*
Sweden / epidemiology
Reg. No./Substance:
0/Narcotics; 300-62-9/Amphetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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