Document Detail


Social peers rescue autism-relevant sociability deficits in adolescent mice.
MedLine Citation:
PMID:  20928844     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well-replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain-typical high sociability. BTBR controls reared with BTBR showed their strain-typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20-day intervention was as effective as a 40-day intervention for improving social approach behavior. High levels of repetitive self-grooming in BTBR were not rescued by peer-rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions.
Authors:
Mu Yang; Kayla Perry; Michael D Weber; Adam M Katz; Jacqueline N Crawley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-10-06
Journal Detail:
Title:  Autism research : official journal of the International Society for Autism Research     Volume:  4     ISSN:  1939-3806     ISO Abbreviation:  Autism Res     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-07-20     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101461858     Medline TA:  Autism Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  17-27     Citation Subset:  IM    
Copyright Information:
This article is a US Government work and, as such is in the public domain in the United States for America © 2010 International Society for Autism Research, Wiley Periodicals, Inc.
Affiliation:
Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892-3730, USA. yangmu@mail.nih.gov
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MeSH Terms
Descriptor/Qualifier:
Age Factors
Animals
Child
Child Development Disorders, Pervasive / genetics*,  physiopathology,  rehabilitation*
Communication*
DNA Mutational Analysis
Disease Models, Animal*
Genotype
Heterozygote Detection
Humans
Mice
Mice, Neurologic Mutants
Peer Group*
Phenotype
Social Behavior*
Social Environment
Stereotyped Behavior / physiology
Synapses / genetics
Grant Support
ID/Acronym/Agency:
ZIA MH002179-25/MH/NIMH NIH HHS
Comments/Corrections
Comment In:
Autism Res. 2011 Feb;4(1):1-4   [PMID:  21328567 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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