| Social peers rescue autism-relevant sociability deficits in adolescent mice. | |
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MedLine Citation:
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PMID: 20928844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Behavioral therapies are currently the most effective interventions for treating the diagnostic symptoms of autism. We employed a mouse model of autism to evaluate components of behavioral interventions that improve sociability in mice. BTBR T+tf/J (BTBR) is an inbred mouse strain that exhibits prominent behavioral phenotypes with face validity to all three diagnostic symptom categories of autism, including robust and well-replicated deficits in social approach and reciprocal social interactions. To investigate the role of peer interactions in the development of sociability, BTBR juvenile mice were reared in the same home cage with juvenile mice of a highly social inbred strain, C57BL/6J (B6). Subject mice were tested as young adults for sociability and repetitive behaviors. B6 controls reared with B6 showed their strain-typical high sociability. BTBR controls reared with BTBR showed their strain-typical lack of sociability. In contrast, BTBR reared with B6 as juveniles showed significant sociability as young adults. A 20-day intervention was as effective as a 40-day intervention for improving social approach behavior. High levels of repetitive self-grooming in BTBR were not rescued by peer-rearing with B6, indicating specificity of the intervention to the social domain. These results from a robust mouse model of autism support the interpretation that social enrichment with juvenile peers is a beneficial intervention for improving adult outcome in the social domain. This novel paradigm may prove useful for discovering factors that are essential for effective behavioral treatments, and biological mechanisms underlying effective behavioral interventions. |
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Authors:
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Mu Yang; Kayla Perry; Michael D Weber; Adam M Katz; Jacqueline N Crawley |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural Date: 2010-10-06 |
Journal Detail:
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Title: Autism research : official journal of the International Society for Autism Research Volume: 4 ISSN: 1939-3806 ISO Abbreviation: Autism Res Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-07-20 Revised Date: 2013-05-27 |
Medline Journal Info:
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Nlm Unique ID: 101461858 Medline TA: Autism Res Country: United States |
Other Details:
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Languages: eng Pagination: 17-27 Citation Subset: IM |
Copyright Information:
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This article is a US Government work and, as such is in the public domain in the United States for America © 2010 International Society for Autism Research, Wiley Periodicals, Inc. |
Affiliation:
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Laboratory of Behavioral Neuroscience, Intramural Research Program, National Institute of Mental Health, NIH, Bethesda, Maryland 20892-3730, USA. yangmu@mail.nih.gov |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Animals Child Child Development Disorders, Pervasive / genetics*, physiopathology, rehabilitation* Communication* DNA Mutational Analysis Disease Models, Animal* Genotype Heterozygote Detection Humans Mice Mice, Neurologic Mutants Peer Group* Phenotype Social Behavior* Social Environment Stereotyped Behavior / physiology Synapses / genetics |
| Grant Support | |
ID/Acronym/Agency:
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ZIA MH002179-25/MH/NIMH NIH HHS |
| Comments/Corrections | |
Comment In:
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Autism Res. 2011 Feb;4(1):1-4
[PMID:
21328567
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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