Document Detail


Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment.
MedLine Citation:
PMID:  23450289     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects.
METHODS: Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range of social (facial affect perception, emotional regulation, empathic accuracy, mental state attribution, and self-referential memory) and nonsocial (speed of processing, attention/vigilance, working memory, verbal memory, visual memory, and reasoning/problem solving) cognitive tasks.
RESULTS: For each social cognitive task, patients with bipolar disorder did not differ significantly from comparison subjects, and both groups performed better than schizophrenia patients. Within the bipolar group, clinical features and medication status were not related to social cognitive performance. Bipolar patients showed performance patterns across tasks (i.e., profiles) that were similar to those of comparison subjects on both social and nonsocial cognitive domains, whereas both groups differed from schizophrenia patients for both domains. Regarding relative impairment across the two cognitive domains, results revealed a significant group-by-domain interaction in which bipolar patients showed less impaired social than nonsocial cognition, while schizophrenia patients showed the opposite pattern.
CONCLUSIONS: Bipolar patients showed less impairment on social relative to nonsocial cognitive performance, whereas schizophrenia patients showed more impairment on social relative to nonsocial cognitive performance. These results suggest that these two cognitive domains play different roles in bipolar disorder compared with in schizophrenia.
Authors:
Junghee Lee; Lori Altshuler; David C Glahn; David J Miklowitz; Kevin Ochsner; Michael F Green
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  170     ISSN:  1535-7228     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-03-01     Completed Date:  2013-04-15     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  334-41     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Attention
Bipolar Disorder / diagnosis*,  psychology
Cognition Disorders / diagnosis*,  psychology
Emotional Intelligence
Emotions
Empathy
Facial Expression
Female
Humans
Interpersonal Relations
Male
Memory Disorders / diagnosis,  psychology
Memory, Episodic
Middle Aged
Neuropsychological Tests
Personal Construct Theory
Problem Solving
Recognition (Psychology)
Schizophrenia / diagnosis*
Schizophrenic Psychology
Social Adjustment*
Social Behavior Disorders / diagnosis*,  psychology
Social Perception
Theory of Mind
Grant Support
ID/Acronym/Agency:
MH-043292/MH/NIMH NIH HHS; MH-089634/MH/NIMH NIH HHS; R01 MH093676/MH/NIMH NIH HHS; R21 MH097007/MH/NIMH NIH HHS; RC1 MH089634/MH/NIMH NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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