|Social and nonsocial cognition in bipolar disorder and schizophrenia: relative levels of impairment.|
|PMID: 23450289 Owner: NLM Status: MEDLINE|
|OBJECTIVE: This study aimed to determine the relative extent of impairment in social and nonsocial cognitive domains in patients with bipolar disorder compared with schizophrenia patients and healthy comparison subjects.
METHODS: Sixty-eight clinically stable outpatients with bipolar disorder, 38 clinically stable outpatients with schizophrenia, and 36 healthy comparison subjects completed a range of social (facial affect perception, emotional regulation, empathic accuracy, mental state attribution, and self-referential memory) and nonsocial (speed of processing, attention/vigilance, working memory, verbal memory, visual memory, and reasoning/problem solving) cognitive tasks.
RESULTS: For each social cognitive task, patients with bipolar disorder did not differ significantly from comparison subjects, and both groups performed better than schizophrenia patients. Within the bipolar group, clinical features and medication status were not related to social cognitive performance. Bipolar patients showed performance patterns across tasks (i.e., profiles) that were similar to those of comparison subjects on both social and nonsocial cognitive domains, whereas both groups differed from schizophrenia patients for both domains. Regarding relative impairment across the two cognitive domains, results revealed a significant group-by-domain interaction in which bipolar patients showed less impaired social than nonsocial cognition, while schizophrenia patients showed the opposite pattern.
CONCLUSIONS: Bipolar patients showed less impairment on social relative to nonsocial cognitive performance, whereas schizophrenia patients showed more impairment on social relative to nonsocial cognitive performance. These results suggest that these two cognitive domains play different roles in bipolar disorder compared with in schizophrenia.
|Junghee Lee; Lori Altshuler; David C Glahn; David J Miklowitz; Kevin Ochsner; Michael F Green|
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|Type: Journal Article; Research Support, N.I.H., Extramural|
|Title: The American journal of psychiatry Volume: 170 ISSN: 1535-7228 ISO Abbreviation: Am J Psychiatry Publication Date: 2013 Mar|
|Created Date: 2013-03-01 Completed Date: 2013-04-15 Revised Date: 2013-11-05|
Medline Journal Info:
|Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: United States|
|Languages: eng Pagination: 334-41 Citation Subset: AIM; IM|
|Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, USA. email@example.com|
|APA/MLA Format Download EndNote Download BibTex|
Bipolar Disorder / diagnosis*, psychology
Cognition Disorders / diagnosis*, psychology
Memory Disorders / diagnosis, psychology
Personal Construct Theory
Schizophrenia / diagnosis*
Social Behavior Disorders / diagnosis*, psychology
Theory of Mind
|MH-043292/MH/NIMH NIH HHS; MH-089634/MH/NIMH NIH HHS; R01 MH093676/MH/NIMH NIH HHS; R21 MH097007/MH/NIMH NIH HHS; RC1 MH089634/MH/NIMH NIH HHS|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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