| Social motivation in recently weaned rats is modified by opiates. | |
| | |
MedLine Citation:
|
PMID: 9445088 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
An open field choice test was used to determine whether maternal deprivation enhanced the motivation to stay close to the mother. Pups could choose between the dam, 3 sisters and 3 unknown animals of the same age. In addition, an empty enclosure identical to those that contained the stimulus animals were present as a nonsocial choice. Rats that were separated from their mother at 20 days of age and tested about 13 h later were compared to animals that had stayed with the mother until just before the test. It was found that maternal separation increased the time spent close to the mother and reduced that spent close to strangers or an empty enclosure. In fact, weaned animals spent far more time close to the mother than they spent close to any other available choice. Moreover, the mean duration of visits to the mother was much increased during the latter half of the 60-min test. These data were interpreted as showing that the mother had rewarding properties, and that maternal deprivation increased her reward value. In further experiments, the role of opioids for this increase in reward value was evaluated. Morphine enhanced the time spent close to the mother, but only in animals that had been subjected to maternal deprivation for about 13 h. Naloxone had the opposite effect. These data show that the mother's reward value is altered when the activity of opioid systems is modified. It is suggested that the mother acquires rewarding properties because of association with nutritive suckling-induced opioid release. |
| | |
Authors:
|
A Agmo; S Barreau; V Lemaire |
Related Documents
:
|
8884058 - Confronting the prenatal effects of active and passive tobacco smoking on the birth wei... 8315528 - Cigarette smoking among women in oklahoma: before, during, and after pregnancy. 18801888 - Neonatal hair nicotine levels and fetal exposure to paternal smoking at home. 15137888 - Biases of success rate differences shown in binomial effect size displays. 14560948 - Tor: the first 10 years. 15373678 - Neonatal alloimmune thrombocytopenia due to anti-hpa-5b (bra). |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Developmental neuroscience Volume: 19 ISSN: 0378-5866 ISO Abbreviation: Dev. Neurosci. Publication Date: 1997 |
Date Detail:
|
Created Date: 1998-03-05 Completed Date: 1998-03-05 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 7809375 Medline TA: Dev Neurosci Country: SWITZERLAND |
Other Details:
|
Languages: eng Pagination: 505-20 Citation Subset: IM |
Affiliation:
|
Laboratoire de Psychophysiologie, Université de Tours, France. anders.aagmo@pain.se.astra.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Analysis of Variance Animals Female Morphine / pharmacology Motivation* Motor Activity / drug effects, physiology Naloxone / pharmacology Narcotic Antagonists / pharmacology Narcotics / pharmacology* Rats Rats, Wistar Social Behavior* Weaning* |
| Chemical | |
Reg. No./Substance:
|
0/Narcotic Antagonists; 0/Narcotics; 465-65-6/Naloxone; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Pemoline alters dopamine modulation of synaptic responses of neostriatal neurons in vitro.
Next Document: Exposure to in utero irradiation produces disruption of radial glia in rats.