| Social isolation stimulates hippocampal estradiol synthesis. | |
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MedLine Citation:
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PMID: 19114026 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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17beta-estradiol is synthesized de novo in the rat hippocampus. However, the regulatory mechanism of hippocampal estradiol synthesis has remained unclear. We investigated the effects of social isolation on rat hippocampal estradiol synthesis. Rats were divided into two groups: social isolation and pair housed group. Socially isolated rats were housed individually while pair housed rats were housed two per cage for 8 weeks. Social isolation activated the transcription of neurosteroidogenic molecules, including steroidogenic acute regulatory protein (StAR) and CYP19 (cytochrome P450arom). These two molecules are involved in the regulatory step for steroidogenesis and final step of estradiol synthesis. In contrast, the mRNA levels were not affected in rat olfactory bulb. The hippocampal estradiol content was increased in accordance with the increased mRNA levels. The hippocampal estradiol content exhibited correlations with the StAR and P450arom mRNA levels. These data suggest that social isolation may enhance de novo estradiol synthesis in the hippocampus. |
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Authors:
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Eiji Munetsuna; Minoru Hattori; Shota Komatsu; Yuya Sakimoto; Atsuhiko Ishida; Shogo Sakata; Yasushi Hojo; Suguru Kawato; Takeshi Yamazaki |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-12-27 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 379 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-21 Completed Date: 2009-02-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 480-4 Citation Subset: IM |
Affiliation:
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Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University, 1-7-1 Kagamiyama, Higashi-Hiroshima 739-8521, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aromatase / genetics, metabolism Body Weight Estradiol / biosynthesis* Hippocampus / anatomy & histology, enzymology, metabolism* Male Olfactory Bulb / anatomy & histology, enzymology, metabolism Organ Size Rats Rats, Wistar Social Isolation* |
| Chemical | |
Reg. No./Substance:
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50-28-2/Estradiol; EC 1.14.14.1/Aromatase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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