| Social isolation and chronic handling alter endocannabinoid signaling and behavioral reactivity to context in adult rats. | |
| | |
MedLine Citation:
|
PMID: 20394803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Social deprivation in early life disrupts emotionality and attentional processes in humans. Rearing rats in isolation reproduces some of these abnormalities, which are attenuated by daily handling. However, the neurochemical mechanisms underlying these responses remain poorly understood. We hypothesized that post-weaning social isolation alters the endocannabinoid system, a neuromodulatory system that controls emotional responding. We characterized behavioral consequences of social isolation and evaluated whether handling would reverse social isolation-induced alterations in behavioral reactivity to context and the endocannabinoid system. At weaning, pups were single or group housed and concomitantly handled or not handled daily until adulthood. Rats were tested in emotionality- and attentional-sensitive behavioral assays (open field, elevated plus maze, startle and prepulse inhibition). Cannabinoid receptor densities and endocannabinoid levels were quantified in a separate group of rats. Social isolation negatively altered behavioral responding. Socially-isolated rats that were handled showed less deficits in the open field, elevated plus maze, and prepulse inhibition tests. Social isolation produced site-specific alterations (supraoptic nucleus, ventrolateral thalamus, rostral striatum) in cannabinoid receptor densities compared to group rearing. Handling altered the endocannabinoid system in neural circuitry controlling emotional expression. Handling altered endocannabinoid content (prefrontal and piriform cortices, nucleus accumbens) and cannabinoid receptor densities (lateral globus pallidus, cingulate and piriform cortices, hippocampus) in a region-specific manner. Some effects of social isolation on the endocannabinoid system were moderated by handling. Isolates were unresponsive to handling-induced increases in cannabinoid receptor densities (caudal striatum, anterior thalamus), but were sensitive to handling-induced changes in endocannabinoid content (piriform, prefrontal cortices), compared to group-reared rats. Our findings suggest alterations in the endocannabinoid system may contribute to the abnormal isolate phenotype. Handling modifies the endocannabinoid system and behavioral reactivity to context, but surmounts only some effects of social isolation. These data implicate a pivotal role for the endocannabinoid system in stress adaptation and emotionality-related disturbances. |
| | |
Authors:
|
N R Sciolino; M Bortolato; S A Eisenstein; J Fu; F Oveisi; A G Hohmann; D Piomelli |
Related Documents
:
|
21791783 - Barriers to community participation: teens and young adults with spina bifida. 19129113 - The relationship between social behaviour and habitat familiarity in african elephants ... 4067793 - Scale 4 (pd) of the mmpi and the diagnosis antisocial personality. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-04-13 |
Journal Detail:
|
Title: Neuroscience Volume: 168 ISSN: 1873-7544 ISO Abbreviation: Neuroscience Publication Date: 2010 Jun |
Date Detail:
|
Created Date: 2010-05-18 Completed Date: 2010-08-19 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 7605074 Medline TA: Neuroscience Country: United States |
Other Details:
|
Languages: eng Pagination: 371-86 Citation Subset: IM |
Copyright Information:
|
Published by Elsevier Ltd. |
Affiliation:
|
Neuroscience and Behavior Program, Department of Psychology, University of Georgia, Athens, GA 30622, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Attention Behavior, Animal* Brain / metabolism Emotions Endocannabinoids / physiology* Female Handling (Psychology)* Male Maze Learning Rats Rats, Sprague-Dawley Receptors, Cannabinoid / metabolism Signal Transduction Social Isolation* Startle Reaction |
| Grant Support | |
ID/Acronym/Agency:
|
DA021644S1/DA/NIDA NIH HHS; R01 DA021644/DA/NIDA NIH HHS; R01 DA021644-04/DA/NIDA NIH HHS; R21 DA022702/DA/NIDA NIH HHS; R21 DA022702-01/DA/NIDA NIH HHS; R21 DA022702-02/DA/NIDA NIH HHS; R21 DA022702-03/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Endocannabinoids; 0/Receptors, Cannabinoid |
| Comments/Corrections | |
Erratum In:
|
Neuroscience. 2011 Jul 28;187:103 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Muscarinic acetylcholine receptor subtypes expressed by mouse bladder afferent neurons.
Next Document: Anti-Apoptotic Factor z-VAD-fmk Promotes the Survival of Cochlear Hair Cells in a Mouse Model for Hu...