| Social interaction: responses to chlordiazepoxide and the loss of isolation-reared effects with paired-housing. | |
| | |
MedLine Citation:
|
PMID: 9342778 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study investigated the action of chlordiazepoxide (CDP), on the social interaction (SI) of adult rats maintained in one of three housing conditions: (i) group-reared, (ii) isolated from weaning or (iii) paired during adulthood after initial isolation at weaning (pair-housed former isolates; PHFIs). Group-reared rats and PHFIs rats were housed in pairs starting 21 days prior to the first experiment. For these two groups, CDP (2.5 and 5.0 mg/kg) increased SI in unfamiliar, but not familiar (cagemate) pairings. In rats isolated throughout, SI was markedly increased and this was unaffected by CDP. Isolated rats also exhibited increased motor activity (MA) during SI tests, and the MA of both isolates and PHFIs was reduced by CDP. Finally, levels of aggression were very low except in isolates, where a relatively modest increase in aggression was reversed by either pairing or CDP. To summarise, isolation-induced increases in SI and aggression were reversed by pairing, but pairing only attenuated isolation-induced increases in MA. Although CDP reduced the elevated aggression and MA of isolated rats, it had no effect on their elevated SI scores. These data question the permanence of anxiety-related, isolation-induced behavioural changes and stand in contrast to the irreversible anxiogenic profile reported for isolation-reared rats in the elevated X-test. |
| | |
Authors:
|
A L Vale; A M Montgomery |
Related Documents
:
|
8241708 - The function of coenzyme q in mitochondria. 3336348 - Glucuronidation of 7-hydroxycoumarin in periportal and pericentral regions of the lobul... 21787848 - Pharmacokinetics and tissue distribution of schizonepetin in rats. 21956808 - Electrical amygdala kindling. 1398888 - Impaired renal vascular reactivity in prehypertensive dahl salt-sensitive rats. 17613108 - Effect of ingested sulfite on hippocampus antioxidant enzyme activities in sulfite oxid... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Psychopharmacology Volume: 133 ISSN: 0033-3158 ISO Abbreviation: Psychopharmacology (Berl.) Publication Date: 1997 Sep |
Date Detail:
|
Created Date: 1997-11-20 Completed Date: 1997-11-20 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7608025 Medline TA: Psychopharmacology (Berl) Country: GERMANY |
Other Details:
|
Languages: eng Pagination: 127-32 Citation Subset: IM |
Affiliation:
|
Department of Psychology, London Guildhall University, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Anti-Anxiety Agents / pharmacology* Chlordiazepoxide / pharmacology* Male Motor Activity / drug effects* Rats Social Behavior* Social Isolation* |
| Chemical | |
Reg. No./Substance:
|
0/Anti-Anxiety Agents; 58-25-3/Chlordiazepoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Hypnotic self administration: forced-choice versus single-choice.
Next Document: Characterization of the ethanol-like discriminative stimulus effects of 5-HT receptor agonists as a ...