Document Detail


Social cognition, the male brain and the autism spectrum.
MedLine Citation:
PMID:  23300517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Behavioral studies have shown that, at a population level, women perform better on tests of social cognition and empathy than men. Furthermore Autism Spectrum Disorders (ASDs), which are characterized by impairments in social functioning and empathy, occur more commonly in males than females. These findings have led to the hypothesis that differences in the functioning of the social brain between males and females contribute to the greater vulnerability of males to ASD and the suggestion that ASD may represent an extreme form of the male brain. Here we sought to investigate this hypothesis by determining: (i) whether males and females differ in social brain function, and (ii) whether any sex differences in social brain function are exaggerated in individuals with ASD. Using fMRI we show that males and females differ markedly in social brain function when making social decisions from faces (compared to simple sex judgements) especially when making decisions of an affective nature, with the greatest sex differences in social brain activation being in the inferior frontal cortex (IFC). We also demonstrate that this difference is exaggerated in individuals with ASD, who show an extreme male pattern of IFC function. These results show that males and females differ significantly in social brain function and support the view that sex differences in the social brain contribute to the greater vulnerability of males to ASDs.
Authors:
Jeremy Hall; Ruth C M Philip; Katie Marwick; Heather C Whalley; Liana Romaniuk; Andrew M McIntosh; Isabel Santos; Reiner Sprengelmeyer; Eve C Johnstone; Andrew C Stanfield; Andy W Young; Stephen M Lawrie
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-12-26
Journal Detail:
Title:  PloS one     Volume:  7     ISSN:  1932-6203     ISO Abbreviation:  PLoS ONE     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-09     Completed Date:  2013-07-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101285081     Medline TA:  PLoS One     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e49033     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / physiopathology*
Child
Child Development Disorders, Pervasive / physiopathology*
Cognition / physiology*
Empathy*
Female
Humans
Judgment*
Magnetic Resonance Imaging
Male
Sex Characteristics
Social Media*
Grant Support
ID/Acronym/Agency:
G0600429//Medical Research Council
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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