Document Detail


Social Stress Reduces Forebrain Cell Proliferation In Rainbow Trout (Oncorhynchus Mykiss).
MedLine Citation:
PMID:  21291915     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Compared to mammals, teleost fishe have a very high rate of adult brain cell proliferation. Still little is known about how this process is regulated in comparative models, and what its functional implications are. We investigated the effect of stressful social interaction on brain cell proliferation in size matched rainbow trout pairs after the formation of stable social hierarchies. After 4 days of interaction, socially subordinate fish displayed common signs of chronic stress including reduced feeding behaviour, elevated plasma cortisol levels, and up-regulated brain stem 5-HT activity. The number of newborn cells in the telencephalon was quantified using immunohistochemistry for the exogenously administered S-phase marker BrdU. Subordinate fish had 40% fewer BrdU-positive telencephalic cells compared to isolated controls, while dominant individuals showed a non-significant tendency towards reduced cell proliferation. Cell proliferation in subordinate animals correlated negatively with aggression received immediately after hierarchy formation, indicating that the level of cell division suppression is related to the severity of the social stressor. These findings are comparable to findings in mammalian models of psychosocial stress, indicating that the suppressive effect of social stress on brain cell proliferation is conserved, and thus likely confers adaptive benefits throughout the vertebrate subphylum.
Authors:
Christina Sørensen; Göran E Nilsson; Cliff H Summers; Oyvind Overli
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-31
Journal Detail:
Title:  Behavioural brain research     Volume:  -     ISSN:  1872-7549     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-2-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier B.V.
Affiliation:
Department of Molecular Biosciences, University of Oslo, P.O. Box 1041, N-0316 Oslo, Norway;
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