Document Detail

Social isolation during peri-adolescence or adulthood: effects on sexual motivation, testosterone and corticosterone response under conditions of sexual arousal in male rats.
MedLine Citation:
PMID:  23347014     Owner:  NLM     Status:  MEDLINE    
Reproductive functions in adult organism are known to be affected by different factors. Effects of social environment at the postnatal ontogenesis attract particular attention since it has deep impact on the development of physiological and emotional state of an individual. Effects of chronic social isolation at different ages on male sexual motivation, testosterone and corticosterone response under conditions of sexual arousal were studied in Wistar rats. After weaning at the 21st [corrected] day of age, rats of one group were isolated for six weeks and after that they were housed in groups of five per cage for ten weeks (Iso3-9). Rats of the second group were housed in groups of five animals per cage till 13 weeks of age, and then they were isolated for six weeks (Iso13-19). Rats of the control group were housed in groups during the experiment. Adult 19 week- old male rats were tested under conditions of sexual arousal. The expression of sexual motivation was estimated as the behavioral activity of a male at the transparent perforated partition separating a receptive female. Isolation of adult male rats reduced the number of approaches to the partition, while the period of time a male spent at the partition was not changed and testosterone response was enhanced as compared to control rats. Chronic social isolation during peri-adolescence reduced sexual motivation and prevented arousal-induced elevation of testosterone. Plasma corticosterone increases at sexual arousal in the two groups of isolated rats did not differ from that in controls. Our results are evidence that social isolation during the post-maturity stage (Iso13-19) did not diminish the manifestation of sexual motivation and hormonal response to a receptive female, while isolation during peri-adolescence attenuated behavioral and hormonal expression of sexual arousal in adult males.
Tamara G Amstislavskaya; Veta V Bulygina; Maria A Tikhonova; Larissa N Maslova
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Chinese journal of physiology     Volume:  56     ISSN:  0304-4920     ISO Abbreviation:  Chin J Physiol     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-25     Completed Date:  2013-06-20     Revised Date:  2013-07-18    
Medline Journal Info:
Nlm Unique ID:  7804502     Medline TA:  Chin J Physiol     Country:  China (Republic : 1949- )    
Other Details:
Languages:  eng     Pagination:  36-43     Citation Subset:  IM    
Laboratory of Behavioral Neurogenomics, Institute of Cytology and Genetics Siberian Branch of Russian Academy of Sciences, Lavrentyev Ave., 10, Novosibirsk 630090, Russia.
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MeSH Terms
Corticosterone / blood*
Motivation / physiology*
Sexual Behavior, Animal*
Social Isolation*
Testosterone / blood*
Reg. No./Substance:
50-22-6/Corticosterone; 58-22-0/Testosterone
Erratum In:
Chin J Physiol. 2013 Apr 30;56(2):127

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