| Social deficits, stereotypy and early emergence of repetitive behavior in the C58/J inbred mouse strain. | |
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MedLine Citation:
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PMID: 19941908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Mouse lines with behavioral phenotypes relevant to symptoms in neurodevelopmental disorders may provide models to test hypotheses about disease etiology and to evaluate potential treatments. The present studies were designed to confirm and expand earlier work on the intriguing behavioral profile of the C58/J inbred strain, including low social approach and aberrant repetitive movements. Additional tests were selected to reflect aspects of autism, a severe neurodevelopmental disorder characterized by emergence of symptoms early in life, higher prevalence in males, social deficits and abnormal repetitive behavior. Mice from the C57BL/6J inbred strain, which has a similar genetic lineage and physical appearance to C58/J, served as a comparison group. Our results revealed that C58/J mice display elevated activity levels by postnatal day 6, which persist into adulthood. Despite normal olfactory ability, young adult male C58/J mice showed deficits in social approach in the three-chambered choice assay and failed to demonstrate social transmission of food preference. In contrast, female C58/J mice performed similarly to female C57BL/6J mice in both social tests. C58/J mice of both sexes demonstrated abnormal repetitive behaviors, displaying excessive jumping and back flipping in both social and non-social situations. These stereotypies were clearly evident in C58/J pups by postnatal days 20-21, and were also observed in C58/J dams during a test for maternal behavior. Overall, the strain profile for C58/J, including spontaneously developing motor stereotypies emerging early in the developmental trajectory, and social deficits primarily in males, models multiple components of the autism phenotype. |
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Authors:
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Bryce C Ryan; Nancy B Young; Jacqueline N Crawley; James W Bodfish; Sheryl S Moy |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural Date: 2009-11-24 |
Journal Detail:
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Title: Behavioural brain research Volume: 208 ISSN: 1872-7549 ISO Abbreviation: Behav. Brain Res. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-02-15 Completed Date: 2010-05-03 Revised Date: 2011-09-26 |
Medline Journal Info:
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Nlm Unique ID: 8004872 Medline TA: Behav Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 178-88 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Department of Biology, University of Redlands, Redlands, CA 92373, USA. bryce_ryan@redlands.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Analysis of Variance Animals Animals, Newborn Behavior, Animal Body Weight / physiology Choice Behavior / physiology Female Habituation, Psychophysiologic / physiology Interpersonal Relations* Locomotion / physiology* Male Maternal Behavior / physiology Mice Mice, Inbred Strains / physiology* Olfactory Pathways / physiology Social Behavior Disorders / physiopathology* Statistics, Nonparametric Stereotyped Behavior / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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P30 HD003110-39/HD/NICHD NIH HHS; P30HD03110/HD/NICHD NIH HHS; R01 MH073402-04/MH/NIMH NIH HHS; R01 MH73402/MH/NIMH NIH HHS; R21 MH084132/MH/NIMH NIH HHS; R21 MH084132-01A1/MH/NIMH NIH HHS; T32 HD040127-09/HD/NICHD NIH HHS; T32HD40127/HD/NICHD NIH HHS |
| Comments/Corrections | |
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