| Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism. | |
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MedLine Citation:
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PMID: 20815188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Obstructive sleep apnea (OSA) is associated with prothrombotic effects that could lead to venous thromboembolic disease. We performed a prospective cross-sectional study to determine the prevalence of snoring and risk of OSA in patients with acute pulmonary embolism (PE). METHODS: We evaluated 270 consecutive patients who underwent a computed tomographic angiogram for suspected PE. Patients without PE served as a control group. Demographic and clinical characteristics were analyzed. The Berlin Questionnaire was used to determine the presence of snoring and the risk of OSA. A subset of patients also underwent formal nocturnal polysomnography. RESULTS: PE was present in 71 (26%) of the 270 patients who underwent a computed tomographic angiogram. When compared with patients without PE, patients with PE had a significantly higher prevalence of snoring (75% vs 50%, odds ratio = 2.91, 95% confidence interval: 1.60, 5.33, P = 0.001) and an increased risk of having OSA, as defined by the Berlin Questionnaire (65% vs 36%, odds ratio = 3.25, confidence interval: 1.84, 5.72, P < 0.001). Results from the multivariate analysis showed that PE was independently associated with risk of OSA (OR = 2.78, P = 0.001). CONCLUSIONS: We found a higher prevalence of snoring and high risk of OSA in patients diagnosed with acute PE, in comparison with patients in whom PE was suspected but ruled out. This association might be independent of other risks factors common to both OSA and PE. Therefore, OSA may represent a risk factor for the development of PE. |
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Authors:
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Matthew D Epstein; Leopoldo N Segal; Sherin M Ibrahim; Neil Friedman; Rami Bustami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Sleep Volume: 33 ISSN: 0161-8105 ISO Abbreviation: Sleep Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-23 Revised Date: 2011-07-22 |
Medline Journal Info:
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Nlm Unique ID: 7809084 Medline TA: Sleep Country: United States |
Other Details:
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Languages: eng Pagination: 1069-74 Citation Subset: IM |
Affiliation:
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Sleep Disorder Center, Morristown Memorial Hospital, Morristown, NJ, USA. mepstein@pol.net |
| Data Bank Information | |
Bank Name/Acc. No.:
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ClinicalTrials.gov/NCT00409045 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angiography Cross-Sectional Studies Female Genetic Predisposition to Disease / genetics Humans Male Middle Aged Prospective Studies Pulmonary Embolism / epidemiology*, etiology, genetics Risk Factors Sleep Apnea, Obstructive / complications, epidemiology* Snoring / complications, epidemiology* Tomography, X-Ray Computed |
| Comments/Corrections | |
Comment In:
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Sleep. 2010 Aug;33(8):1009-10
[PMID:
20815181
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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