| Sniff nasal inspiratory pressure as a marker of respiratory function in motor neuron disease. | |
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MedLine Citation:
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PMID: 10759449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Vital capacity (VC) and maximum mouth pressures are often used to monitor respiratory function in motor neuron disease (MND), but require the use of a mouthpiece. Sniff nasal inspiratory pressure (SNIP) is a simple and reliable means of measuring inspiratory muscle strength; it does not involve the use of a mouthpiece and might therefore be better than VC or mouth pressures for assessing patients with bulbar disease. SNIP, maximum inspiratory (MIP) and expiratory mouth pressure (MEP), VC and arterial carbon dioxide tension (Pa,CO2) were measured in 59 consecutive patients attending a specialist MND clinic. Thirty-one had bulbar involvement on clinical grounds. Both SNIP and VC were inversely related to Pa,CO2 in nonbulbar patients only. Neither MIP nor MEP were related to Pa,CO2. The 10 patients with an elevated Pa,CO2 (>6 kPa) had significantly lower SNIP and VC than normocapnic patients. Sniff nasal inspiratory pressure can be used to monitor respiratory function in motor neuron disease. It is quick and easy for patients to perform, but otherwise appears to offer little advantage over vital capacity measurement. Patients with bulbar disease are often poor at performing sniff nasal inspiratory pressure manoeuvres, possibly because of upper airway collapse or inability to close the mouth completely during the manoeuvre. |
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Authors:
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M B Chaudri; C Liu; L Watson; D Jefferson; W J Kinnear |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The European respiratory journal Volume: 15 ISSN: 0903-1936 ISO Abbreviation: Eur. Respir. J. Publication Date: 2000 Mar |
Date Detail:
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Created Date: 2000-05-25 Completed Date: 2000-05-25 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: DENMARK |
Other Details:
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Languages: eng Pagination: 539-42 Citation Subset: IM |
Affiliation:
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Dept of Respiratory Medicine, University Hospital, Nottingham, UK. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Female Humans Inhalation Male Middle Aged Motor Neuron Disease / physiopathology* Pressure Respiration* |
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