| Snake venomics of the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei. | |
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MedLine Citation:
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PMID: 18590992 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Venoms from the Armenian mountain vipers Macrovipera lebetina obtusa and Vipera raddei were analyzed by RP-HPLC, N-terminal sequencing, MALDI-TOF mass fingerprinting and CID-MS/MS. The venom proteins of M.l. obtusa and V. raddei belong to 9 and 11 families, respectively. The two mountain viper venoms share bradykinin-potentiating/C-natriuretic peptides, and proteins from the dimeric distegrin, DC-fragment, CRISP, PLA(2), serine proteinase, C-type lectin-like, L-amino acid oxidase, and Zn(2+)-dependent metalloproteinase families, albeit each species exhibits distinct relative abundances. M.l. obtusa and V. raddei venoms contain unique components, e.g. the short disintegrin obtustatin in M.l. obtusa, and Kunitz-type serine proteinase inhibitor and VEGF-like molecules in V. raddei. The toxin formulation of M.l. obtusa and V. raddei venoms may be related to their adaptation to rocky mountain ecosystems. On the other hand, the possibility that the VEGF-like proteins from V. raddei underlie the reported potential therapeutic value of V. raddei venom for regenerating damaged peripheral nerves deserves further investigations. Using a similarity coefficient, we estimate that the similarity of venom proteins between M. l. obtusa and M. l. transmediterranea is less than 4%. Although this result would support the classification of M.l. obtusa and M.l. transmediterranea as different species, additional detailed genomic analyses are also required. |
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Authors:
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Libia Sanz; Naira Ayvazyan; Juan J Calvete |
Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2008-06-03 |
Journal Detail:
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Title: Journal of proteomics Volume: 71 ISSN: 1874-3919 ISO Abbreviation: - Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-11 Completed Date: 2008-11-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101475056 Medline TA: J Proteomics Country: Netherlands |
Other Details:
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Languages: eng Pagination: 198-209 Citation Subset: IM |
Affiliation:
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Instituto de Biomedicina de Valencia, C.S.I.C., Valencia, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Chromatography, High Pressure Liquid Proteome* Proteomics Sequence Analysis, Protein Sequence Homology, Amino Acid Species Specificity Viper Venoms / chemistry*, metabolism Viperidae / classification, metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Proteome; 0/Viper Venoms |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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