| Snake venom: From fieldwork to the clinic: Recent insights into snake biology, together with new technology allowing high-throughput screening of venom, bring new hope for drug discovery. | |
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MedLine Citation:
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PMID: 21271609 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Snake venoms are recognized here as a grossly under-explored resource in pharmacological prospecting. Discoveries in snake systematics demonstrate that former taxonomic bias in research has led to the neglect of thousands of species of potential medical use. Recent discoveries reveal an unexpectedly vast degree of variation in venom composition among snakes, from different species down to litter mates. The molecular mechanisms underlying this diversity are only beginning to be understood. However, the enormous potential that this resource represents for pharmacological prospecting is clear. New high-throughput screening systems offer greatly increased speed and efficiency in identifying and extracting therapeutically useful molecules. At the same time a global biodiversity crisis is threatening the very snake populations on which hopes for new venom-derived medications depend. Biomedical researchers, pharmacologists, clinicians, herpetologists, and conservation biologists must combine their efforts if the full potential of snake venom-derived medications is to be realized. |
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Authors:
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Freek J Vonk; Kate Jackson; Robin Doley; Frank Madaras; Peter J Mirtschin; Nicolas Vidal |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-27 |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: - ISSN: 1521-1878 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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Leiden University, Institute of Biology, Sylvius Laboratory, Leiden, The Netherlands; Netherlands Centre for Biodiversity Naturalis, Leiden, The Netherlands. f.j.vonk@biology.leidenuniv.nl. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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