Document Detail


Smoothelin and intermediate filament proteins in human aortocoronary saphenous vein by-pass grafts.
MedLine Citation:
PMID:  10646837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this immunohistochemical investigation was to study the distribution of the novel cytoskeletal protein smoothelin and the intermediate filament proteins vimentin and desmin in normal human great saphenous vein and in human aortocoronary by-pass vein grafts. Smoothelin was present in most smooth muscle cells in the media of the native vein. In the neointima of the vein grafts that had been in situ for three months or more, smoothelin was, in general, present only in few smooth muscle cells. Desmin was distributed in the same pattern as smoothelin in the native great saphenous vein. When desmin and smoothelin were present in the neointima, smoothelin was detected in more cells than desmin. Vimentin was present in most cells in all wall layers of both the native saphenous vein and the vein grafts. Vascular smooth muscle cells containing vimentin but not desmin or smoothelin are the principal cells in the neointima of human aortocoronary vein grafts. In some grafts, however, all three cytoskeletal proteins were detected in the neointima. The distribution of smoothelin and desmin in aortocoronary vein grafts support the postulate that these proteins are expressed mainly in the contractile smooth muscle cell phenotype.
Authors:
B Johansson; A Eriksson; F Ramaekers; L E Thornell
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Histochemical journal     Volume:  31     ISSN:  0018-2214     ISO Abbreviation:  Histochem. J.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  2000-02-04     Completed Date:  2000-02-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0163161     Medline TA:  Histochem J     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  723-7     Citation Subset:  IM    
Affiliation:
Department of Anatomy, Umeå University, Sweden. bengt.johansson@anatomy.umu.se.
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MeSH Terms
Descriptor/Qualifier:
Aged
Coronary Artery Bypass*
Cytoskeletal Proteins / metabolism*
Desmin / metabolism*
Female
Fluorescein-5-isothiocyanate
Humans
Immunoenzyme Techniques
Male
Middle Aged
Muscle Proteins / metabolism*
Muscle, Smooth, Vascular / metabolism,  pathology
Saphenous Vein / metabolism*,  transplantation
Vimentin / metabolism*
Chemical
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Desmin; 0/Muscle Proteins; 0/SMTN protein, human; 0/Vimentin; 3326-32-7/Fluorescein-5-isothiocyanate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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