Document Detail

Smoothelin in vascular smooth muscle cells.
MedLine Citation:
PMID:  17210475     Owner:  NLM     Status:  MEDLINE    
Smoothelin-A and -B have only been found in fully differentiated contractile smooth muscle cells. They are increasingly used to monitor the smooth muscle cell differentiation process to a contractile or synthetic phenotype. Vascular-specific smoothelin-B is the first smooth muscle cell marker that disappears when vascular tissues are compromised, for example, in atherosclerosis or restenosis. Recently obtained data show that smoothelin deficiency results in a considerable loss of contractile potential and hence in impaired smooth muscle function and suggest that smoothelins are part of the contractile apparatus.
Guillaume J van Eys; Petra M Niessen; Sander S Rensen
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  17     ISSN:  1050-1738     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2007-01-09     Completed Date:  2007-03-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  26-30     Citation Subset:  IM    
Department of Molecular Genetics, Cardiovascular Research Institute Maastricht, University of Maastricht, 6200 MD Maastricht, The Netherlands.
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MeSH Terms
Cytoskeletal Proteins / physiology*
Muscle Contraction / physiology*
Muscle Proteins / physiology*
Muscle, Smooth, Vascular / physiology*
Myocytes, Smooth Muscle / physiology*
Reg. No./Substance:
0/Cytoskeletal Proteins; 0/Muscle Proteins; 0/SMTN protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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