Document Detail


Smooth pursuit and visual scanpaths: Independence of two candidate oculomotor risk markers for schizophrenia.
MedLine Citation:
PMID:  21545243     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: Smooth pursuit and visual scanpath deficits are candidate trait markers for schizophrenia. It is not clear whether eye tracking dysfunction (ETD) and atypical scanpath behaviour are the product of the same underlying neurobiological processes. We have examined co-occurrence of ETD and scanpath disturbance in individuals with schizophrenia and healthy volunteers.
METHODS: Eye movements of individuals with schizophrenia (N = 96) and non-clinical age-matched comparison participants (N = 100) were recorded using non-invasive infrared oculography during smooth pursuit in both predictable (horizontal sinusoid) and less predictable (Lissajous sinusoid) conditions and a free viewing scanpath task.
RESULTS: Individuals with schizophrenia demonstrated scanning deficits in both tasks. There was no association between performance measures of smooth pursuit and scene scanpaths in patient or control groups. Odds ratios comparing the likelihood of scanpath dysfunction when ETD was present, and the likelihood of finding scanpath dysfunction when ETD was absent were not significant in patients or controls in either pursuit variant, suggesting that ETD and scanpath dysfunction are independent anomalies in schizophrenia.
CONCLUSION: ETD and scanpath disturbance appear to reflect independent oculomotor or neurocognitive deficits in schizophrenia. Each task may confer unique information about the pathophysiology of psychosis.
Authors:
Sara A Beedie; Philip J Benson; Ina Giegling; Dan Rujescu; David M St Clair
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-05
Journal Detail:
Title:  The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry     Volume:  13     ISSN:  1814-1412     ISO Abbreviation:  World J. Biol. Psychiatry     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-13     Completed Date:  2012-07-18     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101120023     Medline TA:  World J Biol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  200-10     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Endophenotypes
Eye Movements*
Female
Humans
Male
Ocular Motility Disorders / physiopathology*
Pursuit, Smooth*
Risk Factors
Schizophrenia / physiopathology*
Young Adult
Grant Support
ID/Acronym/Agency:
CZB-4-734//Chief Scientist Office; CZB/4/734//Chief Scientist Office

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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