Document Detail

Smooth pursuit and saccadic abnormalities in first-episode schizophrenia.
MedLine Citation:
PMID:  9626724     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Previous studies of oculomotor dysfunction in schizophrenia have tended to concentrate on abnormalities of smooth pursuit eye tracking in chronic medicated patients. We report the results of a study of smooth pursuit, reflexive and antisaccade performance in drug naive and antipsychotic treated first-episode schizophrenic patients. METHODS: Smooth pursuit and saccadic eye movements were recorded in 36 first-episode schizophrenic patients and 36 controls matched for age and estimated IQ. The schizophrenic patients were divided into drug-naive (N = 17) and antipsychotic treated groups (N = 19). RESULTS: Smooth pursuit velocity gain was significantly lower than controls only in the drug-naive patients. The treated patients did not differ significantly from either the controls or the untreated group. In an antisaccade paradigm both treated and drug-naive schizophrenic patients demonstrated an increased number of errors, but only drug-naive patients also demonstrated an increased latency in initiating correct antisaccades. CONCLUSIONS: These impairments are unlikely to be due to a generalized deficit in oculomotor function in the schizophrenic groups, as there were no differences between the groups in saccadic metrics on a reflexive saccade task. The results show that both smooth pursuit and saccadic abnormalities are present at the onset of schizophrenia and are integral to the disorder.
S B Hutton; T J Crawford; B K Puri; L J Duncan; M Chapman; C Kennard; T R Barnes; E M Joyce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychological medicine     Volume:  28     ISSN:  0033-2917     ISO Abbreviation:  Psychol Med     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-31     Completed Date:  1998-08-31     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  1254142     Medline TA:  Psychol Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  685-92     Citation Subset:  IM    
Department of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Royal Postgraduate Medical School, London.
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MeSH Terms
Antipsychotic Agents / therapeutic use
Chronic Disease
Oculomotor Nerve / drug effects,  physiopathology
Psychiatric Status Rating Scales
Pursuit, Smooth / drug effects,  physiology*
Reaction Time / drug effects,  physiology
Reflex / drug effects,  physiology
Saccades / drug effects,  physiology*
Schizophrenia / diagnosis,  drug therapy,  physiopathology*
Schizophrenic Psychology
Grant Support
//Wellcome Trust
Reg. No./Substance:
0/Antipsychotic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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