Document Detail

Smooth pursuit eye movement and schizotypy in the community.
MedLine Citation:
PMID:  17100535     Owner:  NLM     Status:  MEDLINE    
Deficits in smooth pursuit eye movements are well documented in schizophrenia and schizotypic psychopathology. The status of eye tracking dysfunction (ETD) as an endophenotype for schizophrenia liability is relatively robust. However, the relation of ETD to schizophrenia-related deviance in the general population has not been confirmed. This study examined smooth pursuit eye tracking and schizotypal personality features in the general population. Smooth pursuit eye movement and schizotypal features were measured in 300 adult community subjects. The sample included both sexes, subjects with a wide age and educational range, and subjects with no prior history of psychosis. Primary outcome measures were peak gain (eye velocity/target velocity), catch-up saccade rate, and schizotypal feature scores. Total schizotypal features were significantly associated with decreased peak gain and were associated at the trend level with increased catch-up saccade rate. These associations were essentially unchanged after controlling for age, sex, and intellectual level effects. These data confirm a hypothesized association between schizotypal features and poorer eye tracking performance (principally, peak gain) in the general population as well as support the conceptualization of ETD as an endophenotype for schizophrenia liability.
Mark F Lenzenweger; Gillian A O'Driscoll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of abnormal psychology     Volume:  115     ISSN:  0021-843X     ISO Abbreviation:  J Abnorm Psychol     Publication Date:  2006 Nov 
Date Detail:
Created Date:  2006-11-14     Completed Date:  2006-12-28     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0034461     Medline TA:  J Abnorm Psychol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  779-86     Citation Subset:  IM    
Copyright Information:
(c) 2006 APA, all rights reserved.
Department of Psychology, State University of New York at Binghamton, NY 13902-6000, USA.
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MeSH Terms
Community Mental Health Centers
Mass Screening
Middle Aged
Saccades / physiology*
Schizotypal Personality Disorder / diagnosis,  genetics,  physiopathology*

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