Document Detail

Smooth muscle responses of the rat septal artery are not influenced by surrounding passive cardiac tissue.
MedLine Citation:
PMID:  8307897     Owner:  NLM     Status:  MEDLINE    
We investigated the possible contribution of surrounding passive cardiac tissue to the smooth muscle responses of coronary arteries. The vasoactive properties of the intramyocardial septal artery (outer diameter 350-400 microns) of the rat heart were investigated when it was freed from the surrounding cardiac tissue (dissected artery) and when it remained in the left ventricle and was thus embedded in passive cardiac tissue (in situ). The changes in external diameter relative to the maximal diameter (isoproterenol) resulting from the application of 125 mM KCl and 1,000 microU/ml vasopressin were measured at 37 degrees C, a transmural pressure of 100 cm H2O, and zero flow. In the dissected septal arteries (n = 5) the maximum diameter was 402 +/- 16 microns, while during exposure to KCl and vasopressin the diameter was reduced to 66.1 +/- 4.6% and 74.2 +/- 3.0%, respectively. For the in situ arteries (n = 6), the maximal diameter was 386 +/- 28 microns, a value not statistically different from the dissected vessels and the diameters reduced to 63.2 +/- 5.5% and 65.6 +/- 7.2% due to KCl and vasopressin, respectively. The constrictions of dissected arteries and in situ arteries were statistically not different. The results show that the maximally-dilated diameter and the constriction responses of intramyocardial conduit arteries of the rat heart are not affected by the surrounding passive cardiac tissue.
P Sipkema; P J van der Linden; N Westerhof
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Heart and vessels     Volume:  8     ISSN:  0910-8327     ISO Abbreviation:  Heart Vessels     Publication Date:  1993  
Date Detail:
Created Date:  1994-03-14     Completed Date:  1994-03-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8511258     Medline TA:  Heart Vessels     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  181-5     Citation Subset:  IM    
Free University, Laboratory for Physiology, Amsterdam, The Netherlands.
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MeSH Terms
Arginine Vasopressin / pharmacology
Coronary Vessels / physiology*
Heart / physiology*
Muscle, Smooth, Vascular / physiology*
Potassium Chloride / pharmacology
Rats, Inbred WKY
Vasomotor System / physiology*
Grant Support
Reg. No./Substance:
113-79-1/Arginine Vasopressin; 7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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