Document Detail

Smooth muscle phenotypic plasticity in mechanical obstruction of the small intestine.
MedLine Citation:
PMID:  18557891     Owner:  NLM     Status:  MEDLINE    
Chronic, partial obstruction of the small intestine can dramatically alter peristaltic contractile properties. Morphological studies have revealed hypertrophy of the circular smooth muscle cells in the constricted part of the intestine. In this issue of Neurogastroenterology and Motility, Chen et al. show that hyperplasia and hypertrophy of intestinal smooth muscle cells occur at distinct times in response to partial obstruction of the ileum. Furthermore, the first evidence is provided to link intestinal smooth muscle remodelling during mechanical obstruction with changes in serum response factor and two of its co-regulating factors, myocardin and Elk-1.
J A MacDonald
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  20     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-18     Completed Date:  2008-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  737-40     Citation Subset:  IM    
Department of Biochemistry and Molecular Biology, Snyder Institute of Infection, Immunity and Inflammation & Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, AB, Canada.
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MeSH Terms
Hypertrophy / pathology
Intestinal Obstruction*
Intestine, Small* / anatomy & histology,  pathology,  physiology
Muscle, Smooth* / cytology,  physiology
Nerve Net / physiology
Nuclear Proteins / metabolism
Peristalsis / physiology
Serum Response Factor / metabolism
Trans-Activators / metabolism
ets-Domain Protein Elk-1 / metabolism
Reg. No./Substance:
0/Nuclear Proteins; 0/Serum Response Factor; 0/Trans-Activators; 0/ets-Domain Protein Elk-1; 0/myocardin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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