| Smooth muscle cell proliferation and restenosis after stand alone coronary excimer laser angioplasty. | |
| | |
MedLine Citation:
|
PMID: 1999639 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
It has been shown that coronary excimer laser angioplasty can remove atherosclerotic intracoronary tissue. Stand alone coronary excimer laser angioplasty was successfully performed in a 53 year old white man with 90% stenosis of the left anterior descending coronary artery and exertional angina (Canadian Cardiovascular Society class III). The lesion was reduced to a 30% residual stenosis with use of a 1.2 mm and subsequently a 1.8 mm diameter laser catheter. Early follow-up angiography 24 h later revealed persistent patency and unchanged lesion diameter of the target vessel. The patient was free of symptoms during the 2 month follow-up period, but died suddenly while playing in a tennis tournament 63 days after the procedure. Postmortem histologic examination revealed 80% restenosis at the lesion site without plaque disruption or thrombosis. Specific staining of the histologic specimen for smooth muscle cells using alpha-actin revealed significant smooth muscle cell proliferation at the site of coronary excimer laser angioplasty. However, most of the vessel narrowing appeared to be due to underlying fibrotic plaque as a result of insufficient tissue ablation. This was probably related to the size of the currently available catheters, which are too small to create a large channel. |
| | |
Authors:
|
K R Karsch; K K Haase; M Wehrmann; S Hassenstein; H Hanke |
Related Documents
:
|
8888669 - Explaining discrepant mortality results between primary percutaneous transluminal coron... 2976329 - Percutaneous transluminal coronary angioplasty in multivessel coronary disease patients... 20819829 - Coronary vein angioplasty to facilitate implantation of left ventricular lead. 6227879 - Percutaneous transluminal coronary angioplasty in patients with unstable angina. 16325819 - Efficacy of peroxisome proliferative activated receptor (ppar)-alpha ligands, fenofibra... 10348119 - How good are experienced interventional cardiologists in predicting the risk and diffic... 20488299 - Prevention of atrial fibrillation by renin-angiotensin system inhibition a meta-analysis. 11000589 - Left ventricular apical thrombus and myocardial viability: a dobutamine stress echocard... 9098689 - Cardioprotection with a novel adenosine regulating agent mediated by intravascular aden... |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Journal of the American College of Cardiology Volume: 17 ISSN: 0735-1097 ISO Abbreviation: J. Am. Coll. Cardiol. Publication Date: 1991 Mar |
Date Detail:
|
Created Date: 1991-04-09 Completed Date: 1991-04-09 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8301365 Medline TA: J Am Coll Cardiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 991-4 Citation Subset: AIM; IM |
Affiliation:
|
Department of Internal Medicine, University of Tuebingen, Federal Republic of Germany. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angioplasty, Laser* Constriction, Pathologic / pathology, surgery Coronary Artery Disease / pathology, surgery* Coronary Vessels / pathology*, surgery Humans Male Middle Aged Muscle, Smooth, Vascular / pathology* Recurrence |
| Comments/Corrections | |
Comment In:
|
J Am Coll Cardiol. 1991 Mar 15;17(4):995-6
[PMID:
1999640
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Value of ventricular electrogram recordings in the diagnosis of arrhythmias precipitating electrical...
Next Document: Methicillin-resistant Staphylococcus aureus in extended-care facilities: experiences in a Veterans' ...