Document Detail


Smooth muscle cell outgrowth from coronary atherectomy specimens in vitro is associated with less time to restenosis and expression of a key Transcription factor KLF5/BTEB2.
MedLine Citation:
PMID:  14557694     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Atherectomy specimens offer an opportunity to study the biology of coronary artery lesions. We cultured smooth muscle cells (SMCs) from specimens obtained from 24 patients with coronary restenosis after angioplasty to study the relationship between activity of SMCs (in vitro outgrowth) and the time course of restenosis. We also examined expression of a Kruppel-like zinc-finger transcription factor 5 (KLF; also known as BTEB2 and IKLF), which is markedly induced in activated SMCs, in the same specimens. SMC outgrowth was observed in 9 of 24 specimens (37.5%). Restenosis occurred sooner (p < 0.01) in patients whose specimens showed outgrowth compared to those whose specimens showed no outgrowth. Immunostaining for KLF5 was more common in specimens with outgrowth (89 vs. 20%, p < 0.01). These data suggest that the number of activated SMCs in lesions may determine in vitro outgrowth and also affect the time to restenosis.
Authors:
Hironosuke Sakamoto; Tetsuo Sakamaki; Tsugiyasu Kanda; Yo-ichi Hoshino; Yoshie Sawada; Mahito Sato; Hiroko Sato; Yuko Oyama; Akihiko Nakano; Shin-ichi Takase; Akira Hasegawa; Ryozo Nagai; Masahiko Kurabayashi
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  100     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  2003  
Date Detail:
Created Date:  2003-10-14     Completed Date:  2004-04-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  80-5     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Affiliation:
Department of General Medicine, Gunma University School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. sakamoth@med.gunma-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Atherectomy, Coronary*
Cells, Cultured
Coronary Restenosis / epidemiology,  metabolism*,  surgery*
Coronary Vessels / cytology,  metabolism,  pathology
Female
Follow-Up Studies
Humans
Kruppel-Like Transcription Factors
Male
Middle Aged
Myocytes, Smooth Muscle / metabolism*,  pathology*
Risk Factors
Statistics as Topic
Time Factors
Trans-Activators / biosynthesis*
Chemical
Reg. No./Substance:
0/KLF5 protein, human; 0/Kruppel-Like Transcription Factors; 0/Trans-Activators

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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