Document Detail


Smooth muscle cell contraction increases the critical buckling pressure of arteries.
MedLine Citation:
PMID:  23261241     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent in vitro experiments demonstrated that arteries under increased internal pressure or decreased axial stretch may buckle into the tortuous pattern that is commonly observed in aging or diseased arteries in vivo. It suggests that buckling is a possible mechanism for the development of artery tortuosity. Vascular tone has significant effects on arterial mechanical properties but its effect on artery buckling is unknown. The objective of this study was to determine the effects of smooth muscle cell contraction on the critical buckling pressure of arteries. Porcine common carotid arteries were perfused in an ex vivo organ culture system overnight under physiological flow and pressure. The perfusion pressure was adjusted to determine the critical buckling pressure of these arteries at in vivo and reduced axial stretch ratios (1.5 and 1.3) at baseline and after smooth muscle contraction and relaxation stimulated by norepinephrine and sodium nitroprusside, respectively. Our results demonstrated that the critical buckling pressure was significantly higher when the smooth muscle was contracted compared with relaxed condition (97.3mmHg vs 72.9mmHg at axial stretch ratio of 1.3 and 93.7mmHg vs 58.6mmHg at 1.5, p<0.05). These results indicate that arterial smooth muscle cell contraction increased artery stability.
Authors:
Danika M Hayman; Jinzhou Zhang; Qin Liu; Yangming Xiao; Hai-Chao Han
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-12-20
Journal Detail:
Title:  Journal of biomechanics     Volume:  46     ISSN:  1873-2380     ISO Abbreviation:  J Biomech     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-02-08     Completed Date:  2013-09-06     Revised Date:  2014-02-25    
Medline Journal Info:
Nlm Unique ID:  0157375     Medline TA:  J Biomech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  841-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arteries / drug effects,  physiology*
Biomechanical Phenomena
Blood Pressure / physiology
Carotid Artery, Common / drug effects,  physiology
Muscle Contraction / drug effects,  physiology
Muscle, Smooth, Vascular / drug effects,  physiology*
Nitroprusside / pharmacology
Norepinephrine / pharmacology
Organ Culture Techniques
Perfusion
Sus scrofa
Vasoconstriction / drug effects,  physiology
Grant Support
ID/Acronym/Agency:
HHSN268201000036C/HL/NHLBI NIH HHS; HL095852/HL/NHLBI NIH HHS; N01-HV-00244/HV/NHLBI NIH HHS; R01 HL075360/HL/NHLBI NIH HHS; R01 HL095852/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
169D1260KM/Nitroprusside; X4W3ENH1CV/Norepinephrine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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