Document Detail

Smooth endoplasmic reticulum aggregations in all retrieved oocytes causing recurrent multiple anomalies: case report.
MedLine Citation:
PMID:  19646689     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To document the relationship between smooth endoplasmic reticulum (SER) aggregations and recurrent fetal anomalies. DESIGN: Case report. SETTING: Private IVF center. PATIENT(S): A 28-year-old woman with an 11-year history of primary infertility. INTERVENTION(S): Three consecutive cycles of intracytoplasmic sperm injection (ICSI) in the same patient. MAIN OUTCOME MEASURE(S): Clinical pregnancy, live birth, fetal anomaly. RESULT(S): In three consecutive ICSI cycles, a total of 59 MII oocytes were retreived in the same patient, all displaying SER aggregations. The fertilization rate per cycle was 80%, 50%, and 42%, respectively. A total of 12 embryos were transferred in three ICSI cycles, of which 11 were grade 1 embryos. Two of the three cycles ended up with clinical ongoing pregnancies but with multiple fetal anomalies. CONCLUSION(S): This is the first case reported with SER aggregations in all retrieved oocytes in three consecutive ICSI cycles. The repetetive multiple fetal anomalies possibly related to oocyte dysmorphism are of concern.
Cem Akarsu; Gamze Cağlar; Kubilay Vicdan; Eran Sözen; Kutay Biberoğlu
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2009-07-30
Journal Detail:
Title:  Fertility and sterility     Volume:  92     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-10-05     Completed Date:  2009-11-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1496.e1-3     Citation Subset:  IM    
Ankara Private IVF Center, Ankara, Turkey.
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MeSH Terms
Abnormalities, Multiple / diagnosis,  etiology*,  pathology
Endoplasmic Reticulum, Smooth / pathology*
Infertility / etiology
Oocyte Retrieval
Oocytes / pathology*,  ultrastructure
Sperm Injections, Intracytoplasmic

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