| Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention. | |
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MedLine Citation:
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PMID: 18199502 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese. METHODS: Endothelium-dependent flow-mediated dilation (FMD) of brachial artery and carotid intima-media thickness (IMT) were measured non-invasively by ultrasound in 616 apparently healthy Chinese (23% smokers), recruited from greater China and the USA. RESULTS: The Chinese smokers had significantly impaired FMD (7.0+/-2.3 vs. 8.2+/-2.5%, p<0.001) and endothelium-independent vasodilation (GTN, 17.4+/-3.9 vs. 18.7+/-4.1%, p=0.001) and thicker IMT (0.61+/-0.13 vs. 0.58+/-0.12 mm, p=0.025). 91% of the smokers were male. Both endothelium-dependent (6.9+/-2.2 vs. 8.0+/-2.5%, p<0.001) and independent (17.3+/-3.5 vs. 18.2+/-3.7%, p=0.047) vasodilation were significantly lower in the male smokers than non-smokers, although their age and cholesterol levels were lower. FMD-to-GTN ratio in the smokers were lower (0.41+/-0.12 vs. 0.45+/-0.13, p=0.005). Multivariate analyses confirmed an independent adverse impact of smoking on vascular functions. There were no consistent interactions between subject location and impact of smoking on FMD and IMT. CONCLUSION: In these apparently healthy native and overseas Chinese subjects, smoking is adversely associated with endothelial dysfunction and arterial wall thickening, with serious implication in atherosclerosis prevention. |
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Authors:
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G Neil Thomas; Ping Chook; Thomas W C Yip; Shu K Kwong; Thomas Y K Chan; Mu Qiao; Xin S Huang; Dong S Guo; Jian Z Feng; Shu W Chan; Hok C Leong; David S Celermajer; Kam S Woo |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-01-15 |
Journal Detail:
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Title: International journal of cardiology Volume: 128 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2008 Aug |
Date Detail:
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Created Date: 2008-07-29 Completed Date: 2008-10-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 172-7 Citation Subset: IM |
Affiliation:
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The Chinese University of Hong Kong, Shatin, Hong Kong, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Asian Americans / statistics & numerical data Asian Continental Ancestry Group* / statistics & numerical data Atherosclerosis / ethnology*, etiology, physiopathology, prevention & control Biological Markers Carotid Arteries / pathology* Case-Control Studies China / epidemiology, ethnology Endothelium, Vascular / physiopathology* Female Hong Kong / epidemiology Humans Linear Models Male Middle Aged Multivariate Analysis Muscle, Smooth, Vascular / physiopathology* Risk Factors San Francisco / epidemiology Smoking / adverse effects* Tunica Intima / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers |
| Comments/Corrections | |
Comment In:
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Int J Cardiol. 2008 Aug 18;128(2):151-3
[PMID:
18485503
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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