Document Detail

Smoking without exception adversely affects vascular structure and function in apparently healthy Chinese: implications in global atherosclerosis prevention.
MedLine Citation:
PMID:  18199502     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Both active and passive smoking are prevalent in China but cardiovascular diseases were less prevalent in the past. We studied the current relationship between surrogate atherosclerosis markers and smoking in Chinese. METHODS: Endothelium-dependent flow-mediated dilation (FMD) of brachial artery and carotid intima-media thickness (IMT) were measured non-invasively by ultrasound in 616 apparently healthy Chinese (23% smokers), recruited from greater China and the USA. RESULTS: The Chinese smokers had significantly impaired FMD (7.0+/-2.3 vs. 8.2+/-2.5%, p<0.001) and endothelium-independent vasodilation (GTN, 17.4+/-3.9 vs. 18.7+/-4.1%, p=0.001) and thicker IMT (0.61+/-0.13 vs. 0.58+/-0.12 mm, p=0.025). 91% of the smokers were male. Both endothelium-dependent (6.9+/-2.2 vs. 8.0+/-2.5%, p<0.001) and independent (17.3+/-3.5 vs. 18.2+/-3.7%, p=0.047) vasodilation were significantly lower in the male smokers than non-smokers, although their age and cholesterol levels were lower. FMD-to-GTN ratio in the smokers were lower (0.41+/-0.12 vs. 0.45+/-0.13, p=0.005). Multivariate analyses confirmed an independent adverse impact of smoking on vascular functions. There were no consistent interactions between subject location and impact of smoking on FMD and IMT. CONCLUSION: In these apparently healthy native and overseas Chinese subjects, smoking is adversely associated with endothelial dysfunction and arterial wall thickening, with serious implication in atherosclerosis prevention.
G Neil Thomas; Ping Chook; Thomas W C Yip; Shu K Kwong; Thomas Y K Chan; Mu Qiao; Xin S Huang; Dong S Guo; Jian Z Feng; Shu W Chan; Hok C Leong; David S Celermajer; Kam S Woo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-01-15
Journal Detail:
Title:  International journal of cardiology     Volume:  128     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2008 Aug 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  172-7     Citation Subset:  IM    
The Chinese University of Hong Kong, Shatin, Hong Kong, China.
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MeSH Terms
Asian Americans / statistics & numerical data
Asian Continental Ancestry Group* / statistics & numerical data
Atherosclerosis / ethnology*,  etiology,  physiopathology,  prevention & control
Biological Markers
Carotid Arteries / pathology*
Case-Control Studies
China / epidemiology,  ethnology
Endothelium, Vascular / physiopathology*
Hong Kong / epidemiology
Linear Models
Middle Aged
Multivariate Analysis
Muscle, Smooth, Vascular / physiopathology*
Risk Factors
San Francisco / epidemiology
Smoking / adverse effects*
Tunica Intima / physiopathology
Reg. No./Substance:
0/Biological Markers
Comment In:
Int J Cardiol. 2008 Aug 18;128(2):151-3   [PMID:  18485503 ]

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