Document Detail

Smoking and symptom effects on the curves of lung function growth and decline.
MedLine Citation:
PMID:  2064125     Owner:  NLM     Status:  MEDLINE    
Numerous studies have examined the natural time course of human lung function growth and decline throughout life. In most of these studies the investigators used statistical models that required a priori assumptions concerning the underlying form or structure of the lung function data, thus introducing possible biases. In this study we used recently developed nonparametric regression (spline) techniques to describe the evolution of lung function measures with age. This procedure yields an optimally fitted smooth curve through the data and estimates of the process velocity and does not require assumptions concerning the underlying shape of the data curves. The lung function growth-velocity curves are used to estimate the age of growth cessation. This technique was applied to the FVC, FEV1, and the FEV1/FVC ratios of 1,295 females and 1,230 males who were tested in at least one of the first nine surveys of the Tucson epidemiologic study of airway obstructive diseases. Data were analyzed stratified according to gender, smoking status, and respiratory symptoms or diseases. The results indicate large differences between the fitted FEV1 and FEV1/FVC smoothed curves of the various subgroups compared with asymptomatic nonsmokers. These differences were most pronounced in the adult symptomatic smokers, who had higher rates of lung function loss that also began at earlier ages, for both sexes. No significant differences were observed between asymptomatic and symptomatic nonsmokers, most likely because of the reduced number of symptomatic nonsmokers, particularly among the males.
D L Sherrill; M D Lebowitz; R J Knudson; B Burrows
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  144     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-08     Completed Date:  1991-08-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  AIM; IM    
Division of Respiratory Sciences, University of Arizona College of Medicine, Tucson 85724.
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MeSH Terms
Body Height
Forced Expiratory Volume
Lung / growth & development*
Models, Biological
Models, Theoretical
Regression Analysis
Respiratory Mechanics*
Respiratory Tract Diseases / etiology,  physiopathology
Sex Factors
Smoking / adverse effects*
Vital Capacity
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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