| Smoking and overweight: negative prognostic factors in stage III epithelial ovarian cancer. | |
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MedLine Citation:
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PMID: 16614126 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Smoking and overweight are associated with poorer prognosis in several cancer types. The prognostic effect of smoking and body mass index (BMI) on ovarian cancer is unknown. METHODS: Ovarian cancer cases were from the Danish MALOVA (MALignant OVArian cancer) study. Information on smoking status and BMI was obtained from a personal interview conducted closely after primary surgery. Cox regression models were used to estimate adjusted hazard ratios (HR) and 95% confidence intervals (95% CI) for ovarian cancer-specific death in relation to smoking variables and BMI. RESULTS: A total of 295 women with stage III epithelial ovarian cancer were identified and followed to death or for a median of 7.3 years (range, 5.4-9.5 years). Median survival time for normal-weight never smokers was 2.8 years (95% CI, 2.3-3.2) compared with 1.2 years (95% CI, 0.8-2.3) for overweight current smokers. Current smokers had a significantly increased risk of ovarian cancer death compared with never smokers in multivariate Cox analysis (HR, 1.65; 95% CI, 1.22-2.24). The negative effect of smoking diminished with increasing time since a former smoker had stopped smoking (HR, 0.89; 95% CI, 0.80-0.98 per 5 years since stop of smoking). Overweight women also had an increased risk of ovarian cancer death (HR, 1.83; 95% CI, 1.38-2.42) compared with normal-weight women. CONCLUSION: Smoking at the time of diagnosis and premorbid overweight were negative prognostic factors for ovarian cancer-specific survival. The negative effect of smoking decreased with increasing time since stop of smoking. |
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Authors:
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Anette Kjaerbye-Thygesen; Kirsten Frederiksen; Estrid V Høgdall; Eva Glud; Lise Christensen; Claus K Høgdall; Jan Blaakaer; Susanne K Kjaer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology Volume: 15 ISSN: 1055-9965 ISO Abbreviation: Cancer Epidemiol. Biomarkers Prev. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-04-14 Completed Date: 2006-11-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9200608 Medline TA: Cancer Epidemiol Biomarkers Prev Country: United States |
Other Details:
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Languages: eng Pagination: 798-803 Citation Subset: IM |
Affiliation:
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Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Body Mass Index* Carcinoma / epidemiology*, mortality Denmark / epidemiology Female Forecasting Humans Middle Aged Neoplasm Staging Obesity / complications* Ovarian Neoplasms / epidemiology*, mortality Prognosis Smoking / adverse effects* Survival Analysis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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