Document Detail


Smoking impacts on prefrontal attentional network function in young adult brains.
MedLine Citation:
PMID:  16937098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: There is abundant evidence from clinical and preclinical studies that acute administration of nicotine has beneficial effects on attentional network function in the brain. In contrast, little is known about potentially neurotoxic effects on the attentional network during neurodevelopmentally critical periods, such as during adolescence and early adulthood. METHODS: Using event-related functional MRI (fMRI), we investigated prefrontal attentional network function in young adults (n=15 regular smokers and n=12 never-smokers; age: 22.6+/-1.5 years). Duration of smoking was 6.9+/-2.3 years (range of 2-10). Smokers were allowed to smoke ad libitum before the fMRI scanning was conducted. RESULTS: As expected from literature, prefrontal attentional network activity was significantly reduced in smokers compared to nonsmokers (Z=2.1; P=0.036). In smokers, we found that the history of smoking duration (years) is directly related to the extent of diminished attentional network activity (R=-0.67; P=0.012). CONCLUSIONS: To our best knowledge, the relationship between the duration of smoking history and prefrontal attentional network function has not yet been reported. This finding might suggest that several years of chronic nicotine abuse may be sufficient to exert long-lasting effects on the brain function of adolescents and young adults.
Authors:
Francesco Musso; Franziska Bettermann; Goran Vucurevic; Peter Stoeter; Andreas Konrad; Georg Winterer
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2006-08-26
Journal Detail:
Title:  Psychopharmacology     Volume:  191     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  159-69     Citation Subset:  IM    
Affiliation:
Department of Psychiatry, Heinrich-Heine University, Bergische Landstr. 2, 40629 Duesseldorf, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Attention / drug effects*
Female
Humans
Image Interpretation, Computer-Assisted
Magnetic Resonance Imaging*
Male
Neural Pathways / drug effects,  physiopathology
Nicotine / adverse effects*
Nicotinic Agonists / adverse effects*
Prefrontal Cortex / drug effects*,  growth & development,  physiopathology
Reaction Time / drug effects
Regression Analysis
Smoking / adverse effects*
Time Factors
Tobacco Use Disorder / physiopathology*
Chemical
Reg. No./Substance:
0/Nicotinic Agonists; 54-11-5/Nicotine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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