Document Detail


Smoking and human reproduction: the effect of adenylate kinase genetic polymorphism.
MedLine Citation:
PMID:  18850517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the possible influence of adenylate kinase genetic variability on the effect of maternal smoking on intrauterine selection and development. Adenylate kinase locus 1 belongs to a family of monophosphate kinases that plays an important role in the synthesis of nucleotides involved in several metabolic functions. Three hundred forty-five newborn consecutive infants from the Caucasian population of Rome and 360 consecutive infants from the Caucasian population of Penne were studied. The proportion of newborns carrying AK1*2 allele was analyzed in relation to smoking and maternal age. The effect of smoking on birth weight was also analyzed in relation to AK1 phenotype and maternal age. Statistical analyses have been performed according to SPSS programs. In offspring of women aged 28 years or less, the proportion of newborns carrying the AK1*2 allele is much higher in smoking than in nonsmoking mothers (13.2% versus 2.6%). Such association is lacking in mothers aged more than 28 years (6.5% versus 9.2%). The negative effects of smoke on birth weight is more marked in AK11 mothers than in AK1*2 carriers. The data suggest that zygotes carrying AK1*2 allele are relatively protected from the damaging effects of smoking, resulting in a relatively higher proportion of newborns carrying this allele among smoking mothers.
Authors:
Fulvia Gloria-Bottini; Andrea Magrini; Adalgisa Pietropolli; Antonio Bergamaschi; Egidio Bottini
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Publication Detail:
Type:  Comparative Study; Journal Article     Date:  2008-10-10
Journal Detail:
Title:  American journal of perinatology     Volume:  26     ISSN:  1098-8785     ISO Abbreviation:  Am J Perinatol     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-02-09     Completed Date:  2009-06-23     Revised Date:  2009-09-04    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  117-21     Citation Subset:  IM    
Affiliation:
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, School of Medicine, Rome, Italy. gloria@med.uniroma2.it
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MeSH Terms
Descriptor/Qualifier:
Adenylate Kinase / genetics*
Adult
Female
Fetal Growth Retardation / genetics*
Humans
Infant, Newborn
Isoenzymes / genetics*
Male
Polymorphism, Genetic
Reproduction / genetics*
Smoking / adverse effects*,  genetics
Chemical
Reg. No./Substance:
0/Isoenzymes; EC 2.7.4.3/Adenylate Kinase; EC 2.7.4.3/adenylate kinase 1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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