| Smoking has no effect on the amino acid composition of apolipoprotein B100 of LDL while directly influencing the antioxidant status. | |
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MedLine Citation:
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PMID: 11890689 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have demonstrated increased plasma levels of oxidised low-density lipoprotein (oxLDL) in chronic smokers, which has been associated with the extent of endothelial dysfunction. In this study we examine the relationship between the amino acid composition of apolipoprotein B100 (apo B) of low-density lipoprotein (LDL), by reverse phase HPLC after precolumn derivatisation, between smokers (> or =40 cigarettes/day) and nonsmokers in relation to their plasma and LDL antioxidant status. While there was a significant difference in the levels of plasma vitamin C and alpha-tocopherol between female smokers and nonsmokers, as well as in the levels of LDL alpha-tocopherol, there was no significant difference in the amino acid composition of apo B between the two groups. |
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Authors:
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Ananth Sekher Pannala; K Richard Bruckdorfer; Catherine A Rice-Evans |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 292 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2002 Mar |
Date Detail:
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Created Date: 2002-03-13 Completed Date: 2002-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 175-83 Citation Subset: IM |
Copyright Information:
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(C)2002 Elsevier Science (USA). |
Affiliation:
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Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King's College London, St. Thomas' Street, London SE1 9RT, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amino Acids / analysis Antioxidants / analysis* Apolipoprotein B-100 Apolipoproteins B / chemistry* Ascorbic Acid / blood Chromatography, High Pressure Liquid Female Humans Lipids / blood Lipoproteins, LDL / analysis, chemistry* Male Smoking* Vitamin E / blood alpha-Tocopherol / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Antioxidants; 0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Lipids; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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