Document Detail

Smoking has no effect on the amino acid composition of apolipoprotein B100 of LDL while directly influencing the antioxidant status.
MedLine Citation:
PMID:  11890689     Owner:  NLM     Status:  MEDLINE    
Previous studies have demonstrated increased plasma levels of oxidised low-density lipoprotein (oxLDL) in chronic smokers, which has been associated with the extent of endothelial dysfunction. In this study we examine the relationship between the amino acid composition of apolipoprotein B100 (apo B) of low-density lipoprotein (LDL), by reverse phase HPLC after precolumn derivatisation, between smokers (> or =40 cigarettes/day) and nonsmokers in relation to their plasma and LDL antioxidant status. While there was a significant difference in the levels of plasma vitamin C and alpha-tocopherol between female smokers and nonsmokers, as well as in the levels of LDL alpha-tocopherol, there was no significant difference in the amino acid composition of apo B between the two groups.
Ananth Sekher Pannala; K Richard Bruckdorfer; Catherine A Rice-Evans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  292     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-13     Completed Date:  2002-04-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  175-83     Citation Subset:  IM    
Copyright Information:
(C)2002 Elsevier Science (USA).
Wolfson Centre for Age Related Diseases, GKT School of Biomedical Sciences, King's College London, St. Thomas' Street, London SE1 9RT, United Kingdom.
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MeSH Terms
Amino Acids / analysis
Antioxidants / analysis*
Apolipoprotein B-100
Apolipoproteins B / chemistry*
Ascorbic Acid / blood
Chromatography, High Pressure Liquid
Lipids / blood
Lipoproteins, LDL / analysis,  chemistry*
Vitamin E / blood
alpha-Tocopherol / analysis*
Reg. No./Substance:
0/Amino Acids; 0/Antioxidants; 0/Apolipoprotein B-100; 0/Apolipoproteins B; 0/Lipids; 0/Lipoproteins, LDL; 0/oxidized low density lipoprotein; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol

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