Document Detail

Smoking habits and plasma lipid peroxide and vitamin E levels in never-treated first-episode patients with schizophrenia.
MedLine Citation:
PMID:  10755079     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lipid peroxidation may be increased in schizophrenia, due to the illness, lifestyle or medication.
AIMS: To determine plasma lipid peroxide levels and serum vitamin E and A levels in first-episode never-treated people with schizophrenia and in controls.
METHOD: Thirty in-patients with a first episode of schizophrenia or schizophreniform psychosis were recruited, as were controls matched for gender, age, smoking and dietary status. Blood samples were taken, smoking status was recorded and body mass index measured.
RESULTS: There were no significant differences between patients and controls in plasma peroxide levels. Seventy-three per cent of the patients smoked. Patients who smoked had a higher mean lipid peroxide level than non-smokers. Seventy-seven per cent of patients and 70% of controls had a ratio of vitamin E to cholesterol of less than 5. Body mass index was lower in patients than in controls.
CONCLUSIONS: As a result of the high prevalence of smoking this group shows increased lipid peroxidation. Low serum ratios of vitamin E to cholesterol in both patients and controls suggest an unsatisfactory diet.
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  176     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-05-04     Completed Date:  2000-05-04     Revised Date:  2013-09-19    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  290-3     Citation Subset:  IM    
Department of Clinical Research, Crichton Royal Hospital, Dumfries.
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MeSH Terms
Body Mass Index
Case-Control Studies
Cholesterol / blood
Lipid Peroxidation
Lipid Peroxides / blood*
Middle Aged
Nutritional Status
Schizophrenia / blood*,  complications
Smoking / adverse effects,  blood*
Vitamin E / blood*
Reg. No./Substance:
0/Lipid Peroxides; 1406-18-4/Vitamin E; 57-88-5/Cholesterol
R G McCreadie / ; J R Paterson / ; C Blacklock / ; D Wiles / ; D J Hall / ; J Graham / ; S McDonald / ; G Morrison / ; A Mitchell / ; J Allardyce / ; J McKane / ; M Hughson / ; C Kelly / ; M Connolly / ; M Turner / ; D Patience / ; J Crean / ; A Yousef / ; K Brown / ; S McCallum / ; A Hay /

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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