Document Detail

Smoking habits and maternal serum alpha-fetoprotein levels during the second trimester of pregnancy.
MedLine Citation:
PMID:  6192839     Owner:  NLM     Status:  MEDLINE    
In a prospective study the influence of cigarette smoking on maternal serum alpha-fetoprotein levels at 16 weeks gestation was examined. Significantly higher levels were found in 120 smokers compared with 138 non-smokers (median 54.0 and 44.3 micrograms/1 respectively, P less than 0.001). No difference in maternal body weight between the two groups could account for the results. The possibility of smoking-induced increased permeability of the placental barrier is discussed.
This work tested the hypothesis that during pregnancy cigarette smokers would exhibit elevated levels of alpha-fetoproteins (AFP), reflecting leakage of an albumin-sized molecule across the placenta or through the membranes. Maternal serum AFP levels of 258 patients at 16 weeks gestation were prospectively studied in a prenatal clinic. Patients of uncertain gestational age, with threatened abortion, fetal death, suspected twins, previous birth of a child with neural-tube defect or maternal diabetes were excluded. Notes were taken on smoking habits and preconception body weight. Maternal AFP levels in 120 smokers were about 20% higher than those of the 138 nonsmokers (median 54.0 and 44.3 mcg/1 respectively, P0.001). There was no difference between the median pregestational weights. Although the results are not proof of a causal association, they are consistent with the hypothesis that maternal smoking in early pregnancy leads to increased leakage of fetal proteins across the placental barrier.
S G Thomsen; L Isager-Sally; A P Lange; N Saurbrey; V Schiølier
Related Documents :
21377469 - Characterizing gonadal and adrenal activity by fecal steroid analyses in pygmy rabbits ...
6824019 - Maternal and fetal cardiovascular effects of nicotine infusion in pregnant sheep.
10843029 - Trends in smoking during pregnancy, wisconsin 1990 to 1996.
1119499 - The safety of lincomycin in pregnancy.
8746299 - Children and smoking: the family circle.
15076629 - Administration of oral probiotic bacteria to pregnant women causes temporary infantile ...
17319339 - Indications for removal of intrauterine contraceptive devices in jos, north-central nig...
12753509 - Maternal adaptation during childbearing in norway, sweden and the united states.
23271379 - Management of influenza in pregnancy.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  90     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1983 Aug 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  716-7     Citation Subset:  AIM; IM; J    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Body Weight
Pregnancy Trimester, Second*
Prospective Studies
alpha-Fetoproteins / analysis*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Induction of suppressor cells in Japanese encephalitis virus infected mice.
Next Document:  Polypeptide clearing in model membranes: an analysis of the partition of gramicidin a' between cadmi...