Document Detail

Smoking and decreased fertilisation rates in vitro.
MedLine Citation:
PMID:  1359264     Owner:  NLM     Status:  MEDLINE    
To examine possible mechanisms for the association between cigarette smoking and reduced fertility, we have measured the concentration of the nicotine metabolite cotinine in ovarian follicular fluid collected at the time of oocyte recovery during treatment for in-vitro fertilisation. In a group of women in whom follicular fluid cotinine could not be detected (limit of accurate measurement 20 ng/ml) 116 oocytes were collected, of which 84 became fertilised (72%), whereas among women with cotinine concentration greater than 20 ng/ml 20/45 (44%) oocytes did so (p < 0.01). The median fertilisation rates for individuals (range 1-8 eggs each) in the high and low cotinine groups were 57% and 75%, respectively (p < 0.05). These findings suggest that infertile women should be advised to stop or reduce smoking generally, and especially before treatment by in-vitro fertilisation.
S K Rosevear; D W Holt; T D Lee; W C Ford; P G Wardle; M G Hull
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Lancet     Volume:  340     ISSN:  0140-6736     ISO Abbreviation:  Lancet     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2985213R     Medline TA:  Lancet     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1195-6     Citation Subset:  AIM; IM    
University of Bristol Department of Obstetrics and Gynaecology, St Michael's Hospital, UK.
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MeSH Terms
Cotinine / analysis*
Fertilization in Vitro / drug effects*
Follicular Fluid / chemistry*
Infertility, Female / etiology
Smoking / adverse effects*
Reg. No./Substance:
Comment In:
Lancet. 1993 Jan 23;341(8839):241   [PMID:  8093520 ]
Lancet. 1992 Dec 5;340(8832):1409-10   [PMID:  1360109 ]
Lancet. 1993 Jan 23;341(8839):240-1   [PMID:  8093519 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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