Document Detail


Smoking and asthma: clinical and radiologic features, lung function, and airway inflammation.
MedLine Citation:
PMID:  16537865     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Smoking may influence the type of airway inflammation observed in asthma and its response to therapy. More studies are needed on how smoking-induced changes in lung function/structure and airway inflammation may result in a change in clinical expression. We compared clinical, physiologic, radiologic, and airway inflammatory features of 22 smoking asthma patients (cigarette smoking history, 14.0 +/- 7.6 pack-years [mean +/- SD]) and 27 nonsmoking asthma patients. Mean age/duration of asthma of smoking and nonsmoking asthma patients were 31 years/14 years and 29 years/17 years, respectively. Quality of life, FEV(1), bronchodilator response, perception of bronchoconstriction, and methacholine responsiveness were similar in the two groups. Compared to nonsmoking asthma patients, smokers had more respiratory symptoms, a lower mean forced expiratory flow at 25 to 75% of FVC, FEV(1)/FVC ratio, and lung diffusion capacity, and a higher functional residual capacity. Induced-sputum neutrophil and bronchial cell counts were higher and exhaled breath condensate pH was more acidic in smoking asthma patients. On high-resolution CT, airway and parenchymal abnormalities were more common in smoking asthma patients than in nonsmokers. In conclusion, compared with nonsmoking asthma patients, smoking asthma patients have features similar to what could be found in early stages of COPD.
Authors:
Louis-Philippe Boulet; Catherine Lemière; Francine Archambault; Guy Carrier; Marie Claire Descary; Francine Deschesnes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chest     Volume:  129     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-15     Completed Date:  2006-04-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  661-8     Citation Subset:  AIM; IM    
Affiliation:
Hôpital Laval, 2725 Chemin Sainte-Foy, Québec, QC, Canada, G1V 4G5. lpboulet@med.ulaval.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Asthma / physiopathology*,  radiography
Bronchoconstriction
Female
Humans
Leukocyte Count
Male
Neutrophils
Quality of Life
Respiratory Function Tests
Smoking / physiopathology*
Sputum / cytology
Tomography, X-Ray Computed / methods

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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