Document Detail

Smoking and antihypertensive medication: interaction between blood pressure reduction and arterial stiffness.
MedLine Citation:
PMID:  16392766     Owner:  NLM     Status:  MEDLINE    
To investigate how cigarette smoking and antihypertensive drug therapy may interact to affect cardiovascular disease, in this prospective study we administered amlodipine to hypertensive smokers and non-smokers and compared blood pressure reduction and indices of arterial stiffness. We measured blood pressure (BP), heart rate (HR), brachial-ankle pulse wave velocity (baPWV), and the carotid augmentation index (AIx) by using a non-invasive automated device in 101 hypertensive patients at baseline and at 1, 3, and 6 months of amlodipine administration (5.0 mg). At baseline, the AIx was significantly lower in smokers (n=27) than in non-smokers (n=74) (27.3% +/- 13.3% vs. 33.3% +/- 11.4%). After amlodipine administration, in both the groups, the mean BP, baPWV, and AIx were significantly reduced; however, the HR did not show a statistically significant difference. The reduction in the baPWV (cm/s) at 1 and 3 months was less marked in smokers than in non-smokers (mean +/- SD: -186.6 +/- 36.5 vs. -283.6 +/- 24.5 at 1 month; -136.6 +/- 42.2 vs. -280.1 +/- 29.6 at 3 months, respectively, both p<0.05). At 6 months, these intergroup differences in the reductions of baPWV disappeared. The blunted reduction of baPWV, particularly at 3 months, was significantly associated with the extent of smoking (lifetime pack-years smoked). Changes observed in the AIx and mean BP were similar between groups throughout the study period. In the short term, cigarette smoking blunts the effect of amlodipine on the reduction of arterial stiffness, independently of the mean BP level.
Yoshio Matsui; Kazuomi Kario; Joji Ishikawa; Satoshi Hoshide; Kazuo Eguchi; Kazuyuki Shimada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  28     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2006-01-05     Completed Date:  2006-01-31     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  631-8     Citation Subset:  IM    
Department of Internal Medicine, Miwa Municipal Hospital, Yamaguchi, Japan.
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MeSH Terms
Amlodipine / pharmacology,  therapeutic use*
Antihypertensive Agents / pharmacology,  therapeutic use*
Arteries / physiopathology*
Arteriosclerosis / etiology,  physiopathology*
Blood Pressure / drug effects*,  physiology
Blood Pressure Determination
Brachial Artery / physiology
Carotid Arteries / physiology
Endothelium, Vascular / drug effects,  physiology
Heart Rate / physiology
Hemodynamics / drug effects
Hypertension / drug therapy*,  physiopathology*
Middle Aged
Prospective Studies
Regression Analysis
Reproducibility of Results
Smoking / physiopathology*
Time Factors
Reg. No./Substance:
0/Antihypertensive Agents; 88150-42-9/Amlodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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