Document Detail

Smoking and anaesthesia: the pharmacological implications.
MedLine Citation:
PMID:  19143696     Owner:  NLM     Status:  MEDLINE    
Anaesthetists are generally familiar with the peri-operative implications of cigarette smoking. Although there are a number of publications dealing with the wider pharmacological implications of cigarette smoking, the specific interactions which are of direct relevance to anaesthetists are less well known. This review gives an overview of those interactions which are of clinical relevance to anaesthetists and provides, where possible, an explanation of the mechanism. Recent improvements in the understanding of biotransformation of drugs, including streamlining of the classification of hepatic enzymes has allowed better understanding of drug interactions and enables the mechanistic prediction of those involving new drugs.
B P Sweeney; M Grayling
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  64     ISSN:  1365-2044     ISO Abbreviation:  Anaesthesia     Publication Date:  2009 Feb 
Date Detail:
Created Date:  2009-01-15     Completed Date:  2009-02-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  England    
Other Details:
Languages:  eng     Pagination:  179-86     Citation Subset:  AIM; IM    
Poole and Royal Bournemouth Hospitals, Bournemouth, BH7 7DW, UK.
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MeSH Terms
Analgesics, Opioid / pharmacokinetics
Anesthetics, Inhalation / pharmacokinetics
Drug Interactions
Enzyme Induction / drug effects
Smoke / analysis*
Smoking / metabolism*
Xenobiotics / pharmacokinetics
Reg. No./Substance:
0/Analgesics, Opioid; 0/Anesthetics, Inhalation; 0/Smoke; 0/Xenobiotics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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