| Smart polymeric micelles as nanocarriers for oligonucleotides and siRNA delivery. | |
| | |
MedLine Citation:
|
PMID: 17150611 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The development of in vivo delivery systems for oligonucleotides and siRNA is strongly desired to achieve their clinical applications. Recently, polyplex micelles, which are formed through an electrostatic interaction between nucleic acid compounds (DNA and RNA) and poly(ethylene glycol) (PEG)-polycation block copolymers, have received much attention due to their nanometric-scaled size and excellent biocompatibility. Here, three types of newly engineered block copolymers were developed to construct polyplex micelles useful for oligonucleotides and siRNA delivery: (1) PEG-polycation diblock copolymers possessing diamine side-chain with distinctive pKa for siRNA encapsulation into polyplex micelles with high endosomal escaping ability, (2) Lactosylated PEG-(oligonucleotide or siRNA) conjugate through acid-labile beta-thiopropionate linkage to construct pH-sensitive PIC micelles, and (3) PEG-poly(methacrylic acid) block copolymer for the construction of organic/inorganic hybrid nanoparticles encapsulating siRNA. |
| | |
Authors:
|
Kazunori Kataoka; Keiji Itaka; Nobuhiro Nishiyama; Yuichi Yamasaki; Motoi Oishi; Yukio Nagasaki |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Nucleic acids symposium series (2004) Volume: - ISSN: 1746-8272 ISO Abbreviation: Nucleic Acids Symp Ser (Oxf) Publication Date: 2005 |
Date Detail:
|
Created Date: 2006-12-07 Completed Date: 2007-06-12 Revised Date: 2007-09-19 |
Medline Journal Info:
|
Nlm Unique ID: 101259965 Medline TA: Nucleic Acids Symp Ser (Oxf) Country: England |
Other Details:
|
Languages: eng Pagination: 17-8 Citation Subset: IM |
Affiliation:
|
Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8656, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Hydrogen-Ion Concentration Micelles Nanoparticles / chemistry* Oligonucleotides, Antisense / administration & dosage* Polyethylene Glycols / chemistry* Polymethacrylic Acids / chemistry* Proteins / chemistry* RNA, Small Interfering / administration & dosage* |
| Chemical | |
Reg. No./Substance:
|
0/Micelles; 0/Oligonucleotides, Antisense; 0/Polyethylene Glycols; 0/Polymethacrylic Acids; 0/Proteins; 0/RNA, Small Interfering; 0/poly(methacrylic acid-ethylene glycol); 0/polyethylene glycol-poly(3-((3-aminopropyl)amino)aspartamide) |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stable and unique DNA duplex motifs.
Next Document: SNPs analysis by use of protected oligonucleotide probes.