Document Detail

Smart photo-thermal triggered bilayer phase transition in AuNPs-liposome to release drug.
MedLine Citation:
PMID:  23286691     Owner:  NLM     Status:  Publisher    
A novel thermosensitive liposomes with embedded Au nanoparticles (AuNPs) in the bilayer of liposomes was prepared by a combination method of film build and supercritical CO2 incubation. The AuNPs-liposomes are possessed of structure of AuNPs embedded in the bilayer and drug encapsulated in the central aqueous compartment. The AuNPs in the liposomes can strongly absorb light energy, efficiently convert the absorbed energy to heat, the localized heat induce phase transition of bilayer of liposomes and release drug. The drug released from the AuNPs-liposomes can be controlled by the irradiation time and AuNPs concentration in the AuNPs-liposomes at room temperature, where the AuNPs was a nano-switch for dominating drug release both spatially and temporally. The results suggested that drug release from the AuNPs-liposomes was due to the photothermic effect inducing phase transition of the liposomes rather than destroying the bilayer of the liposomes.
Xueqin An; Fan Zhang; Yinyan Zhu
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-4
Journal Detail:
Title:  Langmuir : the ACS journal of surfaces and colloids     Volume:  -     ISSN:  1520-5827     ISO Abbreviation:  Langmuir     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-4     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9882736     Medline TA:  Langmuir     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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