| Smart optical probes for near-infrared fluorescence imaging of Alzheimer's disease pathology. | |
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MedLine Citation:
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PMID: 18236039 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: Near-infrared fluorescent probes for amyloid-beta (Abeta) are an exciting option for molecular imaging in Alzheimer's disease research and may translate to clinical diagnostics. However, Abeta-targeted optical probes often suffer from poor specificity and slow clearance from the brain. We are designing smart optical probes that emit characteristic fluorescence signal only when bound to Abeta. METHODS: We synthesized a family of dyes and tested Abeta-binding sensitivity with fluorescence spectroscopy and tissue-staining. RESULTS: Select compounds exhibited Abeta-dependent changes in fluorescence quantum yield, lifetime, and emission spectra that may be imaged microscopically or in vivo using new lifetime and spectral fluorescence imaging techniques. CONCLUSION: Smart optical probes that turn on when bound to Abeta will improve amyloid detection and may enable quantitative molecular imaging in vivo. |
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Authors:
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Scott B Raymond; Jesse Skoch; Ivory D Hills; Evgueni E Nesterov; Timothy M Swager; Brian J Bacskai |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review |
Journal Detail:
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Title: European journal of nuclear medicine and molecular imaging Volume: 35 Suppl 1 ISSN: 1619-7070 ISO Abbreviation: Eur. J. Nucl. Med. Mol. Imaging Publication Date: 2008 Mar |
Date Detail:
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Created Date: 2008-03-20 Completed Date: 2008-05-20 Revised Date: 2008-07-01 |
Medline Journal Info:
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Nlm Unique ID: 101140988 Medline TA: Eur J Nucl Med Mol Imaging Country: Germany |
Other Details:
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Languages: eng Pagination: S93-8 Citation Subset: IM |
Affiliation:
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Alzheimer's Disease Research Unit, Department of Neurology, Massachusetts General Hospital, 114 16th Street, Charlestown, MA 02129, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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pathology* Animals Brain / pathology* Fluorescent Dyes / diagnostic use* Humans Microscopy, Fluorescence / methods* Molecular Probe Techniques* Spectroscopy, Near-Infrared / methods* |
| Grant Support | |
ID/Acronym/Agency:
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AG 026240/AG/NIA NIH HHS; EB 00768/EB/NIBIB NIH HHS; T32 EB 001680/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fluorescent Dyes |
| Comments/Corrections | |
Erratum In:
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Eur J Nucl Med Mol Imaging. 2008 May;35(5):1032 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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