| Smart Poly(N-isopropylacrylamide) Containing Iridium(III) Complexes as Water-Soluble Phosphorescent Probe for Sensing and Bioimaging of Homocysteine and Cysteine. | |
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MedLine Citation:
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PMID: 23060120 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Homocysteine (Hcy) and cysteine (Cys) are two important kinds of amino acids in human bodies. Herein, we synthesized an iridium(III) complex-functionalized poly(N-isopropylacrylamide) and its hydrogel, which could be used as the excellent phosphorescent bioprobe for sensing Hcy and Cys. Their detection can be realized in aqueous system through the variations in absorption and photoluminescence spectra. Furthermore, living cell imaging experiments demonstrate that the phosphorescent bioprobe is membrane permeable and can monitor the changes of Hcy and Cys within living cells. In addition, the probe is also thermoresponsive, and its photoluminescence intensified with increasing temperature. These results suggests that this bioprobe has promising application in biomedical fields. |
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Authors:
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Shujuan Liu; Weili Qiao; Guoyi Cao; Yang Chen; Yun Ma; Yanqin Huang; Xiangmei Liu; Wenjuan Xu; Qiang Zhao; Wei Huang |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-12 |
Journal Detail:
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Title: Macromolecular rapid communications Volume: - ISSN: 1521-3927 ISO Abbreviation: Macromol Rapid Commun Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9888239 Medline TA: Macromol Rapid Commun Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Key Laboratory for Organic Electronics & Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts & Telecommunications (NUPT), 9 Wenyuan Road, Nanjing 210046, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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