Document Detail

Smart poly(N-isopropylacrylamide) containing iridium(III) complexes as water-soluble phosphorescent probe for sensing and bioimaging of homocysteine and cysteine.
MedLine Citation:
PMID:  23060120     Owner:  NLM     Status:  MEDLINE    
Homocysteine (Hcy) and cysteine (Cys) are two important kinds of amino acids in human bodies. Herein, we synthesized an iridium(III) complex-functionalized poly(N-isopropylacrylamide) and its hydrogel, which could be used as the excellent phosphorescent bioprobe for sensing Hcy and Cys. Their detection can be realized in aqueous system through the variations in absorption and photoluminescence spectra. Furthermore, living cell imaging experiments demonstrate that the phosphorescent bioprobe is membrane permeable and can monitor the changes of Hcy and Cys within living cells. In addition, the probe is also thermoresponsive, and its photoluminescence intensified with increasing temperature. These results suggests that this bioprobe has promising application in biomedical fields.
Shujuan Liu; Weili Qiao; Guoyi Cao; Yang Chen; Yun Ma; Yanqin Huang; Xiangmei Liu; Wenjuan Xu; Qiang Zhao; Wei Huang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-10-12
Journal Detail:
Title:  Macromolecular rapid communications     Volume:  34     ISSN:  1521-3927     ISO Abbreviation:  Macromol Rapid Commun     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-03     Completed Date:  2013-06-04     Revised Date:  2014-01-22    
Medline Journal Info:
Nlm Unique ID:  9888239     Medline TA:  Macromol Rapid Commun     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  81-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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MeSH Terms
Acrylamides / chemistry*
Cell Line, Tumor
Cell Survival / drug effects
Coordination Complexes / chemical synthesis,  chemistry*,  toxicity
Cysteine / chemistry*
Fluorescent Dyes / chemistry*
Homocysteine / chemistry*
Hydrogel / chemistry
Iridium / chemistry*
Microscopy, Confocal
Polymers / chemistry*
Water / chemistry
Reg. No./Substance:
0/Acrylamides; 0/Coordination Complexes; 0/Fluorescent Dyes; 0/Polymers; 059QF0KO0R/Water; 0LVT1QZ0BA/Homocysteine; 25189-55-3/poly-N-isopropylacrylamide; 25852-47-5/Hydrogel; 44448S9773/Iridium; K848JZ4886/Cysteine

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