Document Detail

Smallpox and pregnancy: from eradicated disease to bioterrorist threat.
MedLine Citation:
PMID:  12100808     Owner:  NLM     Status:  MEDLINE    
Health care personnel must be prepared for the threat of bioterrorism. Our objective is to educate primary care providers, obstetricians in particular, in the prevention, diagnosis, and treatment of smallpox. Smallpox poses a particularly serious threat because of its high case-fatality rate in unvaccinated populations (no one younger than 25 years has been vaccinated, and older persons have little remaining residual immunity). Routine nonemergency smallpox vaccination is restricted to laboratory staff working with smallpox-related viruses. Under these circumstances, contraindications to vaccination are pregnancy, immunodeficiency, exfoliative skin conditions (eczema), and allergy to vaccine components. In case of an intentional release of the smallpox virus, those directly exposed and their close contacts must be vaccinated and isolated. Under such emergency circumstances, pregnant women exposed to the variola virus should be vaccinated because of the lethality of the disease during pregnancy. Currently, there is a limited supply of vaccine available.
Victor R Suarez; Gary D V Hankins
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Obstetrics and gynecology     Volume:  100     ISSN:  0029-7844     ISO Abbreviation:  Obstet Gynecol     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-08     Completed Date:  2002-08-02     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  0401101     Medline TA:  Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  87-93     Citation Subset:  AIM; IM    
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, The University of Texas Medical Branch, Galveston 77555-0587, USA.
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MeSH Terms
Bioterrorism / prevention & control*
Middle Aged
Pregnancy Complications, Infectious / mortality,  prevention & control*
Primary Prevention / organization & administration
Risk Assessment
Risk Factors
Smallpox / mortality,  prevention & control*
Smallpox Vaccine / administration & dosage*,  adverse effects
Survival Rate
Vaccination / standards*
Reg. No./Substance:
0/Smallpox Vaccine
Comment In:
Obstet Gynecol. 2002 Dec;100(6):1356; author reply 1356   [PMID:  12468187 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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