| Smaller subcortical volumes and cognitive deficits in children with prenatal methamphetamine exposure. | |
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MedLine Citation:
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PMID: 15598544 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this pilot study was to examine possible neurotoxic effects of prenatal methamphetamine (Meth) exposure on the developing brain and on cognition. Meth-exposed children (n=13) and unexposed control subjects (n=15) were evaluated with MRI. Global brain volumes and regional brain structures were quantified. Ten Meth-exposed and nine unexposed children also completed neurocognitive assessments. Meth-exposed children scored lower on measures of visual motor integration, attention, verbal memory and long-term spatial memory. There were no differences among the groups in motor skills, short delay spatial memory or measures of non-verbal intelligence. Despite comparable whole brain volumes in each group, the Meth-exposed children had smaller putamen bilaterally (-17.7%), smaller globus pallidus (left: -27%, right: 30%), smaller hippocampus volumes (left: -19%, right: -20%) and a trend for a smaller caudate bilaterally (-13%). The reduction in these brain structures correlated with poorer performance on sustained attention and delayed verbal memory. No group differences in volumes were noted in the thalamus, midbrain or the cerebellum. In summary, compared with the control group, children exposed to Meth prenatally exhibit smaller subcortical volumes and associated neurocognitive deficits. These preliminary findings suggest prenatal Meth exposure may be neurotoxic to the developing brain. |
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Authors:
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Linda Chang; Lynne M Smith; Christine LoPresti; M Lynn Yonekura; Jennifer Kuo; Irwin Walot; Thomas Ernst |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Psychiatry research Volume: 132 ISSN: 0165-1781 ISO Abbreviation: Psychiatry Res Publication Date: 2004 Dec |
Date Detail:
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Created Date: 2004-12-15 Completed Date: 2005-03-03 Revised Date: 2008-04-17 |
Medline Journal Info:
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Nlm Unique ID: 7911385 Medline TA: Psychiatry Res Country: Ireland |
Other Details:
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Languages: eng Pagination: 95-106 Citation Subset: IM |
Affiliation:
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Department of Medicine, John A. Burns School of Medicine, University of Hawai'I, HI 96813, USA. lchang@hawaii.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Brain / abnormalities* Central Nervous System Stimulants* Child Child, Preschool Cognition Disorders / diagnosis, etiology* Female Humans Magnetic Resonance Imaging Male Maternal Behavior / psychology Methamphetamine* Neuropsychological Tests Pregnancy Prenatal Exposure Delayed Effects* Severity of Illness Index Substance-Related Disorders |
| Grant Support | |
ID/Acronym/Agency:
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1R01 DA12734-02/DA/NIDA NIH HHS; 3 M01 RR00425/RR/NCRR NIH HHS; K24-DA16170/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Central Nervous System Stimulants; 537-46-2/Methamphetamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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